{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:46Z","timestamp":1789715026433,"version":"4.0.1"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Research is warranted to identify lipidomic markers longitudinally associated with tobacco smoking and cessation and examine their associations with cardiovascular risk metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using untargeted liquid chromatography\u2013mass spectrometry, we measured 1542 lipids among 1845 American Indian individuals at 2 visits (~5.5\u2009years apart). Information on smoking and cessation was collected using questionnaires at both visits. Using mixed\u2010effects linear regression, we first identified lipids associated with current smoking between current and never smokers and past smoking between former and never smokers. Random effects were used to account for family relatedness and within\u2010individual correlations across visits. We then investigated whether longitudinal changes in smoking\u2010related lipids were associated with smoking cessation that occurred between baseline and follow\u2010up. We examined the longitudinal associations of a lipidomic score and each lipid with various cardiovascular risk metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Concentrations of 126 named lipids differed between current and never smokers (false discovery rate&lt;0.05), whereas none differed between former and never smokers. Smoking cessation during the study period was associated with a decrease in phosphatidylcholine(p\u201016:0\/2:0)\/phosphatidylcholine(o\u201016:1\/2:0) at false discovery rate &lt;0.05, an upregulated lipid in current smokers. At\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05, cessation was linked to decreases in 8 of 50 upregulated lipids (eg, lysoglycerophospholipids) and increases in 11 of 76 downregulated lipids (eg, sphingomyelins). The lipidomic score and multiple individual lipids were associated with blood pressure, waist circumference, C\u2010reactive protein, fasting glucose, insulin resistance, and insulin sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Current smoking, but not past smoking, is associated with a broad range of lipidomic markers in American Indian individuals. Longitudinal profiling reveals suggestive evidence of lipidomic markers recovering after cessation. Once validated, these findings may elucidate key lipid pathways underlying the effects of smoking and cessation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046020","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:14:01Z","timestamp":1778757241000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Lipidomic Markers of Tobacco Use and Cessation Associated With Cardiovascular Risk Factors: A Longitudinal Study in American Indian Individuals"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1716-9219","authenticated-orcid":false,"given":"Xiaoxiao","family":"Wen","sequence":"first","affiliation":[{"name":"University of South Florida","place":["Tampa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhong","family":"Miao","sequence":"additional","affiliation":[{"name":"University of South Florida","place":["Tampa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2948-477X","authenticated-orcid":false,"given":"Mingjing","family":"Chen","sequence":"additional","affiliation":[{"name":"University of South Florida","place":["Tampa, USA"]},{"name":"Johns Hopkins University","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-3743","authenticated-orcid":false,"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Sciences Center","place":["Oklahoma City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5358-2345","authenticated-orcid":false,"given":"Amanda M.","family":"Fretts","sequence":"additional","affiliation":[{"name":"University of Washington","place":["Seattle, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-8928","authenticated-orcid":false,"given":"Oliver","family":"Fiehn","sequence":"additional","affiliation":[{"name":"University of California\u2010Davis","place":["Davis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3243-2660","authenticated-orcid":false,"given":"Jinying","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of South Florida","place":["Tampa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000773"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.34923"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000757"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph7103816"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP6345"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2023.110941"},{"key":"e_1_3_2_8_2","unstructured":"Prabhakaran D Anand S Gaziano TA Mbanya JC Wu Y Nugent R. 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