{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:55Z","timestamp":1789715035255,"version":"4.0.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">In recent trials, vericiguat reduced adverse cardiovascular outcomes in stable or recently worsening chronic heart failure (HF), although data concerning vericiguat use in the population with acute HF remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This target trial emulation study included 205 patients with acute HF with left ventricular ejection fraction \u226445%. Vericiguat was initiated at discharge in 103 patients. Stabilized inverse probability of treatment weighting was used to adjust for baseline differences. The primary outcomes were 180\u2010day HF rehospitalization and worsening HF events. Secondary end points included New York Heart Association class improvement, cardiac remodeling measured by echocardiography, and safety events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      After stabilized inverse probability of treatment weighting adjustment, vericiguat significantly reduced 180\u2010day HF rehospitalization (16.3% versus 34.2%; hazard ratio [HR], 0.43 [95% CI, 0.23\u20130.80],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.01) and worsening HF events were numerically lower in the vericiguat group (21.2% versus 31.1%; HR, 0.64 [95% CI, 0.36\u20131.15],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.13). However, patients treated with vericiguat showed more significant improvement in New York Heart Association class (odds ratio [OR], 0.70 [95% CI, 0.50\u20130.96],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.03), though there was no significant improvement in left ventricular ejection fraction or left ventricular dimensions. The incidence of adverse events such as hypotension, hyperkalemia, and worsening renal function were comparable between the 2 groups. The beneficial effect of vericiguat was consistent across all prespecified subgroups, regardless of chronic HF history or concomitant of quadruple guideline\u2010directed medical therapy use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with acute HF, initiating vericiguat at discharge was observed to be associated with fewer HF rehospitalization events and improvements in New York Heart Association functional class over 180\u2009days. These results suggest that vericiguat may have potential as a treatment option during the vulnerable postacute phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique Identifier: NCT05799638.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046168","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:09:04Z","timestamp":1773832144000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Vericiguat in Acute Heart Failure: A Target Trial Emulation Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7655-1502","authenticated-orcid":false,"given":"Junlong","family":"Chen","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]},{"name":"Chongqing University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8003-1723","authenticated-orcid":false,"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]},{"name":"Chongqing University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7527-4141","authenticated-orcid":false,"given":"Ruo\u2019nan","family":"Xiao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5769-1429","authenticated-orcid":false,"given":"Ziyang","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"He","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-4452","authenticated-orcid":false,"given":"Xuesong","family":"Wen","sequence":"additional","affiliation":[{"name":"The First 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