{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:54:08Z","timestamp":1781790848143,"version":"3.54.5"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Significant tricuspid regurgitation (TR) leads to right ventricular dysfunction and associated comorbidities. As the receiving chamber for regurgitant volume, the right atrium undergoes significant mechanical remodeling. This study investigated whether right atrial reservoir strain (RArS), a key marker of atrial mechanics, serves as a prognostic indicator for mortality in patients with moderate\u2010to\u2010severe TR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Clinical, laboratory, and echocardiographic data from 289 consecutive patients with TR (grade \u2265+3) were analyzed. RArS was evaluated by 2\u2010dimensional speckle\u2010tracking echocardiography using semiautomated software (TOMTEC; Philips). The cohort was divided into 2 groups by RArS above or below the median value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 239 patients (mean age 82\u2009years, 55% women) were included in the final study. Median RArS was 11.7%. Compared with patients with higher RArS, patients with RArS below median had a higher rate of atrial fibrillation and worse right ventricular function. Lower RArS was also associated with wider inferior vena cava diameter, abnormal cholestatic liver enzymes, and a higher rate of diuretic use. During a median follow\u2010up period of 26\u2009months (interquartile range, 8\u201331), 99 (41%) patients died. Patients with RArS &lt;11.7% had significantly lower survival rates (52% versus 30%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Multivariable analysis showed that lower RArS was independently associated with higher all\u2010cause mortality (odds ratio, 0.92 [95% CI, 0.85\u20130.99];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Impaired RArS assessed by echocardiography is independently associated with all\u2010cause mortality in patients with moderate\u2013severe TR. Serial measurement of RArS can potentially aid in optimizing timing for intervention in patients with TR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046306","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:46:41Z","timestamp":1779706001000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Right Atrial Strain in Patients With Moderate\u2010to\u2010Severe Tricuspid Regurgitation"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2040-020X","authenticated-orcid":false,"given":"Roei","family":"Merin","sequence":"first","affiliation":[{"name":"Tel Aviv Sourasky Medical Center","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3245-2653","authenticated-orcid":false,"given":"Lior","family":"Zornitzki","sequence":"additional","affiliation":[{"name":"School of Medicine","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zahler","sequence":"additional","affiliation":[{"name":"School of Medicine","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oron\u2010Zvi","family":"Shporn","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky Medical Center","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3863-4493","authenticated-orcid":false,"given":"Yoav Niv","family":"Granot","sequence":"additional","affiliation":[{"name":"School of Medicine","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3299-2839","authenticated-orcid":false,"given":"Shmuel","family":"Banai","sequence":"additional","affiliation":[{"name":"School of Medicine","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Baruch","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky Medical Center","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-8242","authenticated-orcid":false,"given":"Yan","family":"Topilsky","sequence":"additional","affiliation":[{"name":"School of Medicine","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Flint","sequence":"additional","affiliation":[{"name":"School of Medicine","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000788"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jez216"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2021.03.007"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab030"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2300525"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.06.022"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.01.007"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae088"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.01.007"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-019-01598-6"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271588"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.059"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.09.036"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy641"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2023-323084"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey116"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jead052"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2024.01.003"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae578"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.08.009"}],"container-title":["Journal 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