{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:45:27Z","timestamp":1782992727434,"version":"3.54.5"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Perivascular adipose tissue (PVAT) attenuation interacts with local and systemic vascular inflammation and consequently contributes to unfavorable clinical outcomes in patients with various cardiovascular diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We retrospectively analyzed consecutive patients with severe aortic stenosis to investigate the association between PVAT attenuation measured before transcatheter aortic valve replacement (TAVR) and subsequent clinical outcomes. PVAT attenuation was measured using computed tomography angiography images around the aortic valve. The primary outcome was defined as major adverse cardiovascular events (MACE), a composite of all\u2010cause death, stroke, and heart failure rehospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      MACE was observed in 23.6% of 233 patients during a median follow\u2010up of 2.2\u2009years. The MACE group had significantly higher PVAT attenuation than the non\u2010MACE group (\u221274.0\u00b19.8 Hounsfield unit [HU] versus \u221278.9\u00b19.2 HU,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.001). In the Cox regression model, higher PVAT attenuation was independently associated with MACE (hazard ratio: 1.52 [95% CI: 1.13\u20132.04],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.006). Incorporating PVAT attenuation into established prognostic factors following TAVR improved the predictive and reclassification performance of MACE risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Elevated PVAT attenuation around the aortic valve was associated with MACE in patients undergoing TAVR. Measuring PVAT attenuation before TAVR can help identify patients at higher risk of developing heart failure or cardiovascular death after TAVR, thereby aiding in treatment strategy decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.umin.ac.jp\/ctr\/\">https:\/\/www.umin.ac.jp\/ctr\/<\/jats:ext-link>\n                      ; Unique Identifier: UMIN000057107.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046324","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:35:01Z","timestamp":1773138901000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Perivascular Adipose Tissue Attenuation Around the Aortic Valve on Clinical Outcomes After Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0795-6895","authenticated-orcid":false,"given":"Hiroya","family":"Okamoto","sequence":"first","affiliation":[{"name":"Kobe University Graduate School of Medicine","place":["Kobe, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0205-928X","authenticated-orcid":false,"given":"Takayoshi","family":"Toba","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Medicine","place":["Kobe, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2092-4360","authenticated-orcid":false,"given":"Yoichiro","family":"Sugizaki","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Medicine","place":["Kobe, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6810-447X","authenticated-orcid":false,"given":"Hiroyuki","family":"Kawamori","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Medicine","place":["Kobe, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6111-1846","authenticated-orcid":false,"given":"Takashi","family":"Hiromasa","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Medicine","place":["Kobe, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Medicine","place":["Kobe, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2688-3468","authenticated-orcid":false,"given":"Yu","family":"Izawa","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Medicine","place":["Kobe, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0177-0173","authenticated-orcid":false,"given":"Yuto","family":"Osumi","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Medicine","place":["Kobe, 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