{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:30:35Z","timestamp":1793802635697,"version":"4.6.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Beyond average blood pressure (BP) levels, short\u2010term BP fluctuations may carry important prognostic information. However, the clinical significance of within\u2010visit BP changes remains limited. This study aimed to evaluate the association between within\u2010visit BP changes and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We analyzed data from the UK Biobank. BP was measured twice, with at least 1\u2009minute between measurements, while participants were seated. Within\u2010visit BP changes were defined as the absolute difference between 2 consecutive systolic BP measurements, and participants were categorized into within\u2010visit BP changes quartiles. The primary outcome was all\u2010cause mortality, and secondary outcomes included new\u2010onset hypertension and major adverse cardiovascular events (nonfatal myocardial infarction, nonfatal stroke, and heart failure). Multivariable Cox proportional hazards models, adjusted for demographics, cardiovascular risk factors, comorbidities, and baseline BP, were used to estimate hazard ratios (HRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Higher within\u2010visit BP changes were associated with elevated systolic and diastolic BP and a higher incidence of hypertension. All\u2010cause mortality and major adverse cardiovascular events increased progressively across BP changes quartiles, and these results remained consistent in fully adjusted models. Compared with the lowest quartile, the highest quartile showed an elevated risk of all\u2010cause mortality (HR, 1.070 [95% CI, 1.041\u20131.100]), nonfatal myocardial infarction (HR,1.070 [95% CI, 1.021\u20131.121]), stroke (HR,1.086 [95% CI, 1.027\u20131.148]), and heart failure (HR,1.069 [95% CI, 1.015\u20131.127]). BP changes as a continuous variable demonstrated a significant linear association without evidence of nonlinearity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Within\u2010visit BP changes are independently associated with the development of hypertension, mortality, and major adverse cardiovascular events, supporting its potential role as a marker of long\u2010term cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046365","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:29:52Z","timestamp":1782210592000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Within\u2010Visit Blood Pressure Changes With Cardiovascular Disease and Mortality Among Individuals Without a History of Hypertension: Results From the UK Biobank"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4703-4824","authenticated-orcid":false,"given":"In Tae","family":"Jin","sequence":"first","affiliation":[{"name":"Yonsei University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8764-7995","authenticated-orcid":false,"given":"Seok\u2010Jae","family":"Heo","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-9549","authenticated-orcid":false,"given":"Jin Young","family":"Park","sequence":"additional","affiliation":[{"name":"Yonsei University Health System","place":["Yongin, Republic of Korea"]},{"name":"Yonsei University College of Medicine","place":["Yongin, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1484-4645","authenticated-orcid":false,"given":"SungA","family":"Bae","sequence":"additional","affiliation":[{"name":"Yonsei University Health System","place":["Yongin, Republic of Korea"]},{"name":"Yongin Severance Hospital","place":["Yongin, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","volume-title":"Hypertension","author":"World Health Organization","year":"2023","unstructured":"World Health Organization . Hypertension. Geneva: World Health Organization; 2023. Updated September 7, 2023. https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/hypertension"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30752-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530440051036"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803180"},{"key":"e_1_3_2_6_2","volume-title":"HEARTS: Technical Package for Cardiovascular Disease Management in Primary Health Care","author":"World Health Organization","year":"2018","unstructured":"World Health Organization . HEARTS: Technical Package for Cardiovascular Disease Management in Primary Health Care. Geneva: World Health Organization; 2018. 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Algorithmically Defined Outcomes (ADOs) Version 2.0. 2022. https:\/\/biobank.ndph.ox.ac.uk\/showcase\/ukb\/docs\/alg_outcome_main.pdf."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.5603\/pjnns.94839"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200000004-00003"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-020-0421-5"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.116368"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.11.007"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx246"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.046365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:20:24Z","timestamp":1793802024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.046365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":32,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7,7]]}},"alternative-id":["10.1161\/JAHA.125.046365"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.046365","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"2025-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e046365"}}