{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:35Z","timestamp":1789715015759,"version":"4.0.1"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Magnesium mitigates several mechanisms involved in secondary brain injury after cardiac arrest. Because systemically administered magnesium crosses the blood\u2013brain barrier poorly, it may be unsuitable for early post\u2010cardiac arrest neuroprotection. We tested whether intrathecal magnesium (IT\u2010Mg), which bypasses the blood\u2013brain barrier, improves neurologic outcomes in a porcine model of asphyxial cardiac arrest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Twenty\u2010four pigs underwent asphyxial cardiac arrest and cardiopulmonary resuscitation. Thirty minutes after return of spontaneous circulation, the IT\u2010Mg group received 75\u2009mg of magnesium via cranial intrathecal catheters; the control group received no IT\u2010Mg treatment. Animals were observed for up to 72\u2009hours post return of spontaneous circulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Survival duration and cumulative survival did not differ significantly between groups. In controls, the mean amplitude\u2010integrated electroencephalography amplitude remained depressed for 24\u2009hours, whereas it increased in the IT\u2010Mg group (group\u00d7time interaction\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Compared with controls, the IT\u2010Mg group demonstrated superior neurologic function (lower overall performance category, group effect\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.039; lower neurologic deficit score, group effect\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.013) and reduced histologic injury (lower temporal cortical [\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.038] and total [\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.041] histologic damage scores).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Intrathecal administration of magnesium after return of spontaneous circulation mitigated histologic injury and improved neurologic function in a porcine model of asphyxial cardiac arrest.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046439","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:24:27Z","timestamp":1774430667000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Intrathecal Magnesium Administration on Neurologic Outcomes in a Porcine Model of Asphyxial Cardiac Arrest"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-6754","authenticated-orcid":false,"given":"Hyoung Youn","family":"Lee","sequence":"first","affiliation":[{"name":"Chonnam National University Hospital","place":["Gwangju, Republic of Korea"]},{"name":"Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2188-874X","authenticated-orcid":false,"given":"Najmiddin","family":"Mamadjonov","sequence":"additional","affiliation":[{"name":"Chonnam National University Graduate School","place":["Gwangju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7279-2419","authenticated-orcid":false,"given":"Wan Young","family":"Heo","sequence":"additional","affiliation":[{"name":"Chonnam National University Hospital","place":["Gwangju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon","family":"Heo","sequence":"additional","affiliation":[{"name":"Chonnam National University Hospital","place":["Gwangju, Republic of 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