{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:10:17Z","timestamp":1778343017909,"version":"3.51.4"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sleep behaviors influence the development of chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD), but their role in the dynamic transitions of COPD and CHD and their interaction with genetic susceptibility on the comorbidity remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using UK Biobank data, Cox proportional hazard models and multistate survival models were used to examine the associations of sleep patterns with the risk of dynamic transitions of COPD and CHD, and their interaction with polygenic risk score for comorbidity of COPD and CHD. Four\u2010way decomposition models were performed to explore the potential mediating roles of inflammatory biomarkers and metabolites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">During a median follow\u2010up of 13.8\u2009years, 10\u2009481 and 30\u2009194 new\u2010onset cases of CODP and CHD were recorded among 388\u2009972 participants, respectively. A healthy sleep pattern was associated with a lower risk of transition from COPD to comorbid CHD (hazard ratio [HR], 0.72 [95% CI, 0.59\u20130.88]), and from CHD to comorbid COPD (HR, 0.81 [95% CI, 0.67\u20130.99]). Compared with participants having low genetic risk for comorbidity of COPD and CHD and a healthy sleep pattern, participants with high genetic risk and a poor sleep pattern had the highest risk of comorbidity of COPD and CHD (HR, 2.81 [95% CI, 1.50\u20135.30]). Additionally, C\u2010reactive protein and glycoprotein acetyls were the strongest mediators, explaining 12.40% and 7.00% of the associations between sleep patterns and the incident comorbidity of COPD and CHD, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our findings revealed that a healthy sleep pattern played an important role in the dynamic transitions of COPD and CHD, partially through inflammatory pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046469","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:24:44Z","timestamp":1774430684000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Joint Associations of Sleep Patterns and Genetic Susceptibility With Dynamic Transitions of Chronic Obstructive Pulmonary Disease and Coronary Heart Disease and the Mediating Role of Inflammatory Biomarkers and Metabolites"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-7064","authenticated-orcid":false,"given":"Yanyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Peking University","place":["Beijing, China"]},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0737-3785","authenticated-orcid":false,"given":"Pingxiu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Peking University","place":["Beijing, China"]},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darui","family":"Gao","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Peking University","place":["Beijing, China"]},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmeng","family":"Ji","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Peking University","place":["Beijing, China"]},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Nursing, Peking Union Medical College, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2036-4285","authenticated-orcid":false,"given":"Yiwen","family":"Dai","sequence":"additional","affiliation":[{"name":"School of Nursing, Peking Union Medical College, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-0387","authenticated-orcid":false,"given":"Yuling","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Nursing, Peking Union Medical College, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2767-2600","authenticated-orcid":false,"given":"Fanfan","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Nursing, Peking Union Medical College, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7527-1022","authenticated-orcid":false,"given":"Wuxiang","family":"Xie","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Peking University","place":["Beijing, China"]},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(22)00470-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)00757-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","unstructured":"Fabbri LM Celli BR Agust\u00ed A Criner GJ Dransfield MT Divo M Krishnan JK Lahousse L de Montes Oca M Salvi SS et\u00a0al. 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