{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:45:22Z","timestamp":1782992722611,"version":"3.54.5"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Anemia has emerged as a risk factor for cerebral venous thrombosis (CVT) and has been associated with poorer outcomes. A specific association has been observed with microcytic anemia, most commonly caused by iron deficiency anemia (IDA). However, detailed data on the clinical, radiological, and therapeutic profile of CVT in patients with IDA remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We analyzed consecutive patients with CVT and moderate or severe IDA from the prospective Lariboisi\u00e8re Hospital cohort with CVT (1998\u20132023). Patients with other types of anemia were excluded. Clinical, neuroimaging, treatment, and outcome data were compared with those of patients with CVT without anemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 616 patients with CVT, 64 (10.4%) had moderate or severe IDA. Most were women (96.9%), with chronic gynecological bleeding (eg, fibroids, adenomyosis) as the predominant cause. All received anticoagulation. Additional treatments included iron supplementation, blood transfusion, gynecological surgery, and gonadotropin\u2010releasing hormone analogs. Compared with patients without anemia (n=502), those with IDA more frequently presented with focal neurological deficits and parenchymal lesions (54.7% versus 35.3%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.0025), particularly venous infarctions (32.8% versus 14.5%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.0002). Despite more severe initial presentations, 1\u2010year functional outcomes did not significantly differ between groups (adjusted odds ratio for excellent outcome associated with IDA, 0.60 [95% CI, 0.23\u20131.52]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">IDA is a prevalent comorbidity in CVT, affecting predominantly young women with benign, treatable causes of IDA. Although associated with more severe initial findings, long\u2010term outcomes did not differ from those of patients without IDA. Appropriate recognition and specific management of IDA should be considered in patients with CVT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046478","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:36:31Z","timestamp":1773138991000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Specific Features of Cerebral Venous Thrombosis Associated With Iron Deficiency Anemia"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9359-0471","authenticated-orcid":false,"given":"Diana","family":"Doukhi","sequence":"first","affiliation":[{"name":"Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]},{"name":"FHU NeuroVasc","place":["Paris, France"]},{"name":"Paris Cit\u00e9 University","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6320-2887","authenticated-orcid":false,"given":"Agnes","family":"Aghetti","sequence":"additional","affiliation":[{"name":"Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]},{"name":"FHU NeuroVasc","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6509-8964","authenticated-orcid":false,"given":"Virginie","family":"Siguret","sequence":"additional","affiliation":[{"name":"Paris Cit\u00e9 University","place":["Paris, France"]},{"name":"INSERM, U1140","place":["Paris, France"]},{"name":"Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3384-0423","authenticated-orcid":false,"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"CHU Lille","place":["Lille, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9777-6205","authenticated-orcid":false,"given":"Maxime","family":"Delrue","sequence":"additional","affiliation":[{"name":"Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]},{"name":"INSERM U1144","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8498-8857","authenticated-orcid":false,"given":"Peggy","family":"Reiner","sequence":"additional","affiliation":[{"name":"Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]},{"name":"FHU NeuroVasc","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-5975","authenticated-orcid":false,"given":"Georges","family":"Jourdi","sequence":"additional","affiliation":[{"name":"Paris Cit\u00e9 University","place":["Paris, France"]},{"name":"Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]},{"name":"INSERM U1144","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6123-9694","authenticated-orcid":false,"given":"Ludovic","family":"Drouet","sequence":"additional","affiliation":[{"name":"CREATIF, Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7797-2236","authenticated-orcid":false,"given":"Eric","family":"Jouvent","sequence":"additional","affiliation":[{"name":"Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]},{"name":"FHU NeuroVasc","place":["Paris, France"]},{"name":"Paris Cit\u00e9 University","place":["Paris, France"]},{"name":"CERVCO, Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]},{"name":"INSERM, U1141","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0911-8999","authenticated-orcid":false,"given":"Mikael","family":"Mazighi","sequence":"additional","affiliation":[{"name":"Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]},{"name":"FHU NeuroVasc","place":["Paris, France"]},{"name":"Paris Cit\u00e9 University","place":["Paris, France"]},{"name":"INSERM U1144","place":["Paris, France"]},{"name":"CERVCO, Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]},{"name":"A. Rothschild Foundation Hospital","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Crassard","sequence":"additional","affiliation":[{"name":"Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]},{"name":"FHU NeuroVasc","place":["Paris, France"]},{"name":"CERVCO, Lariboisi\u00e8re Hospital, AP\u2010HP","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.039390"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.543884"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000117571.76197.26"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","unstructured":"Triquenot Bagan A Crassard I Drouet L Barbieux\u2010Guillot M Marlu R Robinet\u2010Borgomino E Morange P\u2010E Wolff V Grunebaum L Klapczynski F et\u00a0al. Cerebral venous thrombosis: clinical radiological biological and etiological characteristics of a French prospective cohort (FPCCVT)\u2014comparison with ISCVT cohort. 2021;12:753110. doi: 10.3389\/fneur.2021.753110","DOI":"10.3389\/fneur.2021.753110"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0411-9"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009843"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01772824"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.21.3.488"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.22.3.414a"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738040190070901"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.46.589"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2005.09.020"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","unstructured":"Silvis SM Reinstra E Hiltunen S Lindgren E Heldner MR Mansour M Ghiasian M Jood K Zuurbier SM Groot AE et\u00a0al. Anaemia at admission is associated with poor clinical outcome in cerebral venous thrombosis. 2020;27:716\u2013722. doi: 10.1111\/ene.14148","DOI":"10.1111\/ene.14148"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2022.01606"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-018-0544-6"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1401038"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082952"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jha2.70008"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001309"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31820cccb2"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.20424"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04846.x"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.55729\/2000-9666.1481"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12657"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","unstructured":"Chennupati R Solga I Wischmann P Dahlmann P Celik FG Pacht D \u015eahin A Yogathasan V Hosen MR Gerdes N et\u00a0al. Chronic anemia is associated with systemic endothelial dysfunction. 2023;10:1099069. doi: 10.3389\/fcvm.2023.1099069","DOI":"10.3389\/fcvm.2023.1099069"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104606"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000456"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-4795"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.046478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:12:04Z","timestamp":1782990724000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.046478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3,17]]}},"alternative-id":["10.1161\/JAHA.125.046478"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.046478","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"2025-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e046478"}}