{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:03:00Z","timestamp":1785250980077,"version":"3.55.0"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Hypertension is a common, modifiable risk factor for cardiovascular disease with an increasing occurrence in young adults. We examined the association of lower\u2010than\u2010normal kidney function with\n                      <jats:italic toggle=\"no\">incident<\/jats:italic>\n                      hypertension in young adults (aged 18\u201339\u2009years) compared with middle\u2010aged (aged 40\u201349\u2009years) and older adults (aged 50\u201365\u2009years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We conducted a historical cohort study of 7.8 million individuals (3.7 million aged 18\u201339\u2009years) using linked provincial health care data sets from Ontario, Canada, between 2008 and 2021. Cox models were used to examine the association of categorized estimated glomerular filtration rate (eGFR) (60\u2013100 mL\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ) and incident hypertension, stratified by age (18\u201339, 40\u201349, and 50\u201365\u2009years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among our cohort (mean age, 40.4\u2009years; mean\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">eGFR,<\/jats:styled-content>\n                      104.9\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">mL<\/jats:styled-content>\n                      \/min), a total of 170\u2009905 (4.6%) individuals developed hypertension among young adults, compared with 279\u2009937 (15.3%) in those aged 40 to 49\u2009years and 588\u2009195 (25.2%) in those aged 50 to 65\u2009years. The adjusted rates of hypertension increased with an\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">eGFR<\/jats:styled-content>\n                      of &lt;100 mL\/min, increasing step wise as\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">eGFR<\/jats:styled-content>\n                      declined, and occurred at a higher relative\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">eGFR<\/jats:styled-content>\n                      in young adults compared with older age groups. Among young adults who developed hypertension, cardiovascular events were 6\u2010 to 10\u2010fold more common and were more likely with minor\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">eGFR<\/jats:styled-content>\n                      reductions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Minor reductions in eGFR in younger adults are associated with new\u2010onset hypertension and a higher risk of cardiovascular consequences, suggesting early identification, monitoring, and management may be beneficial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046502","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:20:12Z","timestamp":1777458012000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Incident Hypertension in Young Adults With a Mild Estimated Glomerular Filtration Rate Reduction"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5622-2700","authenticated-orcid":false,"given":"Sumaiya","family":"Ahmed","sequence":"first","affiliation":[{"name":"The Ottawa Hospital","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-869X","authenticated-orcid":false,"given":"Junayd","family":"Hussain","sequence":"additional","affiliation":[{"name":"University of Ottawa","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6915-7669","authenticated-orcid":false,"given":"Nicholas","family":"Grubic","sequence":"additional","affiliation":[{"name":"Institute of Clinical Evaluative Sciences","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1388-9799","authenticated-orcid":false,"given":"Ayub","family":"Akbari","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital","place":["Ottawa, Canada"]},{"name":"Ottawa Hospital Research Institute, The Ottawa Hospital","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Ravani","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Calgary","place":["Calgary, Canada"]},{"name":"University of Calgary","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-0795","authenticated-orcid":false,"given":"Peter","family":"Tanuseputro","sequence":"additional","affiliation":[{"name":"The University of Hong Kong","place":["Hong Kong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3559-3531","authenticated-orcid":false,"given":"Gregory L.","family":"Hundemer","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital","place":["Ottawa, Canada"]},{"name":"University of Ottawa","place":["Ottawa, Canada"]},{"name":"Institute of Clinical Evaluative Sciences","place":["Ottawa, Canada"]},{"name":"Ottawa Hospital Research Institute, The Ottawa Hospital","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-8170","authenticated-orcid":false,"given":"Tim","family":"Ramsay","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital","place":["Ottawa, Canada"]},{"name":"Ottawa Hospital Research Institute, The Ottawa Hospital","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5075-6370","authenticated-orcid":false,"given":"Navdeep","family":"Tangri","sequence":"additional","affiliation":[{"name":"Max Rady College of Medicine, University of Manitoba","place":["Winnipeg, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-0451","authenticated-orcid":false,"given":"Ann","family":"Bugeja","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital","place":["Ottawa, Canada"]},{"name":"University of Ottawa","place":["Ottawa, Canada"]},{"name":"Ottawa Hospital Research Institute, The Ottawa Hospital","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Knoll","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital","place":["Ottawa, Canada"]},{"name":"University of Ottawa","place":["Ottawa, Canada"]},{"name":"Ottawa Hospital Research Institute, The Ottawa Hospital","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-0845","authenticated-orcid":false,"given":"Douglas","family":"Maneul","sequence":"additional","affiliation":[{"name":"University of Ottawa","place":["Ottawa, Canada"]},{"name":"Institute of Clinical Evaluative Sciences","place":["Ottawa, Canada"]},{"name":"Ottawa Hospital Research Institute, The Ottawa Hospital","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1936-5133","authenticated-orcid":false,"given":"Maneesh","family":"Sud","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"Institute of Clinical Evaluative Sciences","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9366-3118","authenticated-orcid":false,"given":"Rahul","family":"Chanchlani","sequence":"additional","affiliation":[{"name":"McMaster Children's Hospital","place":["Hamilton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9146-2344","authenticated-orcid":false,"given":"Manish M.","family":"Sood","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital","place":["Ottawa, Canada"]},{"name":"University of Ottawa","place":["Ottawa, Canada"]},{"name":"Ottawa Hospital Research Institute, The Ottawa Hospital","place":["Ottawa, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19043"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.154"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.2307"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.10.002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000485"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-11072-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001184"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-13-173"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2966"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.117.09855"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020549"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.36.6.692"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2006.02.007"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12405"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt164"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2011.03.003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt067"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-7-200804010-00006"},{"key":"e_1_3_2_20_2","first-page":"20","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","year":"2013","unstructured":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 2013;3:20.","journal-title":"Kidney Int Suppl"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-075062"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.07.012"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.0000000000000066"},{"key":"e_1_3_2_24_2","unstructured":"Sciences TIfCE . ICES home page. https:\/\/www.ices.on.ca\/."},{"key":"e_1_3_2_25_2","unstructured":"Canada S. Population by sex and age group by province and territory (number both sexes). 2016."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001885"},{"key":"e_1_3_2_27_2","unstructured":"Ontario Go . Ontario Laboratories Information System (OLIS) \u2013 information for providers. AOHC EMR Implementation Toolkit. Government of Ontario. 2018."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021010039"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2004080697"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.09.020"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2020020151"},{"key":"e_1_3_2_33_2","first-page":"e18","article-title":"Accuracy of administrative databases in identifying patients with hypertension","volume":"1","author":"Tu K","year":"2007","unstructured":"Tu K, Campbell NR, Chen Z\u2010L, Cauch\u2010Dudek KJ, McAlister FA. Accuracy of administrative databases in identifying patients with hypertension. Open Med. 2007;1:e18\u2013e26.","journal-title":"Open Med"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.03.005"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/pst.2257"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12939-018-0800-6"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.123839"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","unstructured":"Hux JE Ivis F Flintoft V Bica A. Diabetes in Ontario. Determination of prevalence and incidence using a validated administrative data algorithm. 2002;25:512\u2013516. doi: 10.2337\/diacare.25.3.512","DOI":"10.2337\/diacare.25.3.512"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/20543581211017408"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229218"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-19425-7_4"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.02450314"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61272-0"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5087"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09801"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2017040421"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2016020154"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-020-04534-2"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-3-200608010-00006"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0073-8"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2005111153"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.Cir.0000158434.69180.2d"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2018.01.015"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0003912021"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.046502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:47:16Z","timestamp":1785250036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.046502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5,5]]}},"alternative-id":["10.1161\/JAHA.125.046502"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.046502","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,5]]},"assertion":[{"value":"2025-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e046502"}}