{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:02:58Z","timestamp":1785250978518,"version":"3.55.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Methamphetamine\u2010associated acute coronary syndrome (ACS) has not been previously well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This retrospective, single\u2010center study included all patients aged 18 to 65\u2009years who presented with ACS and underwent coronary angiography from 2012 to 2022. Patients who used cocaine or had other non\u2010type 1 myocardial infarction were excluded. Cox proportional hazard regression and survival analyses were performed to assess all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      One hundred ninety\u2010four patients with methamphetamine\u2010associated ACS were identified from 1309 ACS cases, for a prevalence of 14.8%. When compared with the 1115 patients with ACS without methamphetamine use, patients with methamphetamine\u2010associated ACS were mostly younger men with a median age of 52\u2009years (Q1\u2013Q3: 47\u201357) versus 57\u2009years (Q1\u2013Q3: 51\u201361,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). More patients with methamphetamine\u2010associated ACS were found to have nonobstructive coronary diseases (24.2% versus 10.6%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Despite being younger and having a lower burden of traditional risk factors, patients with methamphetamine\u2010associated ACS experienced significantly lower survival (log\u2010rank test,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.005), a pattern that persisted after adjustment for confounders. In multivariable Cox regression, methamphetamine use emerged as the strongest independent predictor of all\u2010cause mortality, with an adjusted hazard ratio of 2.08 (95% CI, 1.40\u20133.09;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">ACS related to methamphetamine use is primarily observed in younger men with adverse social determinants of health and is strongly associated with mortality. Strategies for prevention unique to this population are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046514","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:30:18Z","timestamp":1777455018000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Methamphetamine Use Among Adult Patients Presenting With Acute Coronary Syndrome: A Single\u2010Center Retrospective Cohort Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5410-1056","authenticated-orcid":false,"given":"Susan X.","family":"Zhao","sequence":"first","affiliation":[{"name":"Santa Clara Valley Medical Center","place":["San Jose, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4773-793X","authenticated-orcid":false,"given":"William","family":"Xu","sequence":"additional","affiliation":[{"name":"Emory University","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Jaradeh","sequence":"additional","affiliation":[{"name":"Santa Clara Valley Medical Center","place":["San Jose, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8353-9612","authenticated-orcid":false,"given":"Andres","family":"Deluna","sequence":"additional","affiliation":[{"name":"Santa Clara Valley Medical Center","place":["San Jose, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakara","family":"Seng","sequence":"additional","affiliation":[{"name":"Santa Clara Valley Medical Center","place":["San Jose, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Santa Clara Valley Medical Center","place":["San Jose, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Santa Clara Valley Medical Center","place":["San Jose, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-2278","authenticated-orcid":false,"given":"Michael H.","family":"Crawford","sequence":"additional","affiliation":[{"name":"University of California, San Francisco","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14688"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312461"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-022-10261-7"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000888"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016704"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.03.030"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(08)70628-4"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023663"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2015.45.2.158"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.5114\/amsad.2020.95381"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.01.027"},{"key":"e_1_3_1_13_2","first-page":"8","article-title":"Acute coronary syndrome and crystal methamphetamine use: a case series","volume":"63","author":"Wijetunga M","year":"2004","unstructured":"Wijetunga M, Bhan R, Lindsay J, Karch S. 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