{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:53:52Z","timestamp":1781790832819,"version":"3.54.5"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Preadmission \u03b2\u2010blocker (BB) use may convey cardioprotective effects after onset of cardiogenic shock (CS). It is unknown whether this also holds for patients with the most severe forms of CS receiving venoarterial extracorporeal membrane oxygenation (V\u2010A ECMO) support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a multicenter observational cohort study including adult patients supported by V\u2010A ECMO for severe CS between February 2018 and January 2025. Patients who had taken BBs within 48\u2009hours before ECMO initiation as part of their home medication were compared with those who had not. The primary end point was ECMO weaning failure at 30\u2009days; a composite of death, ongoing or renewed ECMO support, or the need for heart replacement therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 307 patients were included in the study, of whom 87 (28.3%) were in the BB group. ECMO weaning failure occurred in 40 patients (46.0%) in the BB group compared with 126 (57.3%) patients in the non\u2010BB group (log\u2010rank test,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.08). No significant difference was seen in the trend of hemodynamic and metabolic parameters during ECMO support. Multivariable Cox proportional hazards regression analyses showed that preadmission BB use was significantly associated with a decreased risk for ECMO weaning failure (hazard ratio, 0.61 [95% CI, 0.40\u20130.91]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this study, BB use before the onset of severe CS in patients supported by V\u2010A ECMO was significantly associated with lower inotrope requirements and lower rates of ECMO weaning failure. Future studies are needed to confirm these results and investigate the potential and feasibility of continuing low dosages of BBs during CS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique Identifier: NCT05444764.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046530","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:50:09Z","timestamp":1779706209000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Preadmission \u03b2\u2010Blocker Use and Venoarterial Extracorporeal Membrane Oxygenation Weaning Failure in Patients With Cardiogenic Shock"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3880-2605","authenticated-orcid":false,"given":"Myrthe P. J.","family":"van Steenwijk","sequence":"first","affiliation":[{"name":"Erasmus Medical Center","place":["Rotterdam, the Netherlands"]},{"name":"Cardiovascular Institute, Erasmus MC","place":["Rotterdam, the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3276-4736","authenticated-orcid":false,"given":"Laurens P.","family":"Uitbeijerse","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center","place":["Rotterdam, the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4672-5691","authenticated-orcid":false,"given":"Lara C. A.","family":"Pladet","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center","place":["Rotterdam, the Netherlands"]},{"name":"University Medical Center Utrecht","place":["Utrecht, the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2974-5030","authenticated-orcid":false,"given":"Atreyu","family":"van Esch","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center","place":["Rotterdam, the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9553-5814","authenticated-orcid":false,"given":"Yannick","family":"Taverne","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center","place":["Rotterdam, the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk W.","family":"Donker","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht","place":["Utrecht, the 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