{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:45:11Z","timestamp":1782992711887,"version":"3.54.5"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study aimed to evaluate secular trends in the control of major risk factors at the time of ischemic stroke to assess the real\u2010world implementation of prevention guidelines and identify areas needing greater clinical attention for improved early stroke outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We retrospectively analyzed data from a prospective, multicenter, nationwide registry of consecutive patients with acute ischemic stroke between 2011 and 2022. For risk factor controls of interest, hypertension, diabetes, dyslipidemia, and atrial fibrillation (AF) were considered. Well\u2010controlled risk factors were defined as follows: \u201cwell\u2010controlled hypertension\u201d: hypertension with prior antihypertensive medication and systolic blood pressure &lt;140\u2009mm\u2009Hg on admission; \u201cwell\u2010controlled diabetes\u201d: prior antidiabetic medication with glycated hemoglobin &lt;7.0%; \u201cwell\u2010controlled dyslipidemia\u201d: prior statin therapy with low\u2010density lipoprotein cholesterol &lt;100 mg\/dL; and \u201cwell\u2010controlled AF\u201d: presence of AF with prior oral anticoagulant use. Linear trends in control rates were tested via the Cochran\u2013Armitage and linear contrast tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 76\u2009962 patients (68.8\u00b113.3\u2009years;men, 59.0%), the adjusted rate of well\u2010controlled hypertension decreased from 35.7% (95% CI, 34.0%\u201337.5%) in 2011 to 25.5% (95% CI, 24.4%\u201326.7%) in 2022, whereas well\u2010controlled status improved for diabetes (26.4%\u201329.4%), dyslipidemia (22.2%\u201348.6%), and AF (26.0%\u201355.7%) from 2011 to 2022\u00a0(\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      &lt;0.001). The rates of well\u2010controlled risk factors were relatively higher in patients with a history of stroke than in those with no history of stroke, except for hypertension. The 3\u2010month composite of stroke, myocardial infarction, and all\u2010cause death significantly declined from 10.0% in 2011 to 8.6% in 2022 (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our study confirmed a continuous increase in prestroke risk factor control, including diabetes, dyslipidemia, and AF, but the rate remained suboptimal at stroke onset. These findings may help inform strategies to improve risk factor management by identifying priority areas that warrant targeted intervention in clinical practice and population\u2010level guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046592","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:22:34Z","timestamp":1771590154000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Annual Trends in Risk Factor Control Status at the Time of Ischemic Stroke in South Korea"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-8339","authenticated-orcid":false,"given":"Joon\u2010Tae","family":"Kim","sequence":"first","affiliation":[{"name":"Chonnam National University Medical School","place":["Gwangju, 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Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-6610","authenticated-orcid":false,"given":"Jihoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital","place":["Seongnam, Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6571-7091","authenticated-orcid":false,"given":"Keon\u2010Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea University Guro Hospital","place":["Seoul, Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4199-3024","authenticated-orcid":false,"given":"Jong\u2010Moo","family":"Park","sequence":"additional","affiliation":[{"name":"Eulji University School of Medicine","place":["Uijeongbu, 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