{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:55Z","timestamp":1789715035251,"version":"4.0.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transcatheter edge\u2010to\u2010edge repair of the mitral valve (M\u2010TEER) has shown promising outcomes in patients with advanced heart failure and significant mitral regurgitation. Similarly, outcomes after left ventricular assist device (LVAD) implantation have improved in advanced heart failure with\/without mitral regurgitation. However, the indication of M\u2010TEER in favorable candidates for LVAD therapy remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Potentially favorable LVAD candidates were defined as patients with advanced heart failure and secondary mitral regurgitation who underwent M\u2010TEER and were considered theoretically suitable for LVAD therapy based on data from the optimized catheter valvular intervention (OCEAN)\u2010Mitral registry. Among this cohort, Cox proportional hazards regression analysis was performed to identify factors associated with cardiovascular death following M\u2010TEER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 3764 patients who underwent M\u2010TEER were included. Of them, 129 were identified as potentially favorable LVAD candidates (mean age: 67\u2009years; 67% men). Despite advanced heart failure, procedural success was 96%. The 1\u2010year rate of cardiovascular death was 10.1%, increasing to 38.9% at 3\u2009years. Baseline left ventricular end\u2010diastolic diameter was independently associated with cardiovascular death (hazard ratio: 1.07 per 1\u2010mm increase; 95% CI: 1.02\u20131.12;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.01). In patients with markedly enlarged left ventricles, symptom improvement was limited, and reverse remodeling was not achieved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">M\u2010TEER can be safely performed even in potentially favorable LVAD candidates. However, long\u2010term efficacy appears limited, particularly in those with advanced LV remodeling. Further studies are warranted to establish an optimal strategy, including the role of LVAD therapy versus M\u2010TEER, for this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/center6.umin.ac.jp\/cgi-open-bin\/ctr\/ctr_view.cgi?recptno=R000027188\">https:\/\/center6.umin.ac.jp\/cgi\u2010open\u2010bin\/ctr\/ctr_view.cgi?recptno=R000027188<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046638","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:23:35Z","timestamp":1774430615000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Transcatheter Edge\u2010to\u2010Edge Repair in Potentially Favorable Candidates for Left Ventricular Assist Device: Evidence From the OCEAN\u2010Mitral Registry"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7551-3431","authenticated-orcid":false,"given":"Shuhei","family":"Tanaka","sequence":"first","affiliation":[{"name":"University of Toyama","place":["Toyama, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-7637","authenticated-orcid":false,"given":"Teruhiko","family":"Imamura","sequence":"additional","affiliation":[{"name":"University of Toyama","place":["Toyama, 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