{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:45:18Z","timestamp":1782992718814,"version":"3.54.5"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Although current cardiopulmonary resuscitation guidelines recommend administering epinephrine at 3\u2010 to 5\u2010minute intervals during advanced life support (ALS), scientific evidence for the optimal dosing interval for enhancing hemodynamic parameters remains limited. Therefore, we compared the hemodynamic effects of 1\u2010, 3\u2010, and 5\u2010minute epinephrine dosing intervals on blood pressure augmentation in a porcine ventricular fibrillation cardiac arrest model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Forty\u2010two pigs were randomly assigned to 1\u2010, 3\u2010, and 5\u2010minute epinephrine dosing\u2010interval groups. After ventricular fibrillation induction and a 2\u2010minute downtime, basic life support was initiated with a 30:2 compression\u2010to\u2010ventilation ratio for 8\u2009minutes, followed by 30\u2009minutes of ALS, including asynchronous ventilation at a rate of a single ventilation every 6\u2009seconds, with oxygen delivered at 15\u2009L\/min. Epinephrine (0.02\u2009mg\/kg) was administered at predetermined intervals of 1, 3, or 5\u2009minutes. We compared the pressure\u2013time integrals for mean blood pressure, coronary perfusion pressure, and diastolic blood pressure among the groups over the 30\u2010minute ALS period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The mean blood pressure (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), coronary perfusion pressure (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.001), and diastolic blood pressure pressure\u2013time integrals (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.005) were significantly higher in the 1\u2010minute group than in the 3\u2010 and 5\u2010minute groups. Crucially, mean blood pressure and coronary perfusion pressure pressure\u2013time integrals remained positive in the 1\u2010minute group but became negative in the 3\u2010 and 5\u2010minute groups during ALS. The diastolic blood pressure pressure\u2013time integral also remained positive for a longer duration in the 1\u2010minute group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">A 1\u2010minute epinephrine dosing interval may be significantly more effective in augmenting blood pressure and critical hemodynamic parameters during ALS than are the currently recommended 3\u2010 or 5\u2010minute intervals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046743","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:43:30Z","timestamp":1772628210000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the Hemodynamic Effects of Epinephrine on Blood Pressure Augmentation at 1\u2010, 3\u2010, and 5\u2010Minute Dosing Intervals"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0092-5356","authenticated-orcid":false,"given":"Gyo Jin","family":"Ahn","sequence":"first","affiliation":[{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]},{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-2466","authenticated-orcid":false,"given":"Kyoung\u2010Chul","family":"Cha","sequence":"additional","affiliation":[{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]},{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4799-6277","authenticated-orcid":false,"given":"Junghun","family":"Lee","sequence":"additional","affiliation":[{"name":"Songho University","place":["Hoengseong, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8867-5072","authenticated-orcid":false,"given":"Yae Jun","family":"Son","sequence":"additional","affiliation":[{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-4943","authenticated-orcid":false,"given":"Young\u2010Il","family":"Roh","sequence":"additional","affiliation":[{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]},{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-0196","authenticated-orcid":false,"given":"Woo Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]},{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5693-2576","authenticated-orcid":false,"given":"Yujin","family":"Lee","sequence":"additional","affiliation":[{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1916-2366","authenticated-orcid":false,"given":"Hyeon Young","family":"Im","sequence":"additional","affiliation":[{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-3181","authenticated-orcid":false,"given":"Sung Oh","family":"Hwang","sequence":"additional","affiliation":[{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of Korea"]},{"name":"Yonsei University Wonju College of Medicine","place":["Wonju, Republic of 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