{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:08:05Z","timestamp":1789553285880,"version":"build-2803163510"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Nonrheumatic valvular heart disease is an increasing public health concern. This study assessed the burden and quality of care for nonrheumatic valvular heart disease in Asia and at the global level from 1990 to 2021, and projected trends to 2050 using data from the GBS (Global Burden of Disease Study) 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Incidence, age\u2010standardized incidence rate, deaths, age\u2010standardized mortality rate, disability\u2010adjusted life years, and age\u2010standardized disability\u2010adjusted life years rate were analyzed. A time\u2010series model (autoregressive integrated moving average was used for forecasting future trends. A quality\u2010of\u2010care index was constructed through principal component analysis, and future quality\u2010of\u2010care index trends were projected using a Bayesian age\u2010period\u2010cohort model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">From 1990 to 2021, both incident nonrheumatic valvular heart disease cases and age\u2010standardized incidence rate increased globally and in Asia, whereas age\u2010standardized mortality rate and age\u2010standardized disability\u2010adjusted life years rate declined. Projections suggest that incident cases will continue to rise through 2050, with age\u2010standardized incidence rate decreasing globally but remaining relatively stable in Asia. Although Asia has lower age\u2010standardized rates than the global average, its projected age\u2010standardized incidence rate increase is greater. Disease burden varied by age and sex, with incidence peaking at 70 to 74\u2009years. Mortality exceeded that of men among women after age 70 to 74. Nonrheumatic aortic valve disease contributed to the greatest burden. Quality\u2010of\u2010care index improved markedly from 1990 to 2021 globally and in Asia, but recent gains have slowed, suggesting a plateau in care improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Nonrheumatic valvular heart disease burden is rising, especially in aging Asian populations. Despite declining mortality and improved care quality, increasing incidence and slowing quality\u2010of\u2010care index gains may intensify future health system pressures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046804","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:51:07Z","timestamp":1781005867000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Comparisons of the Burden and Quality of Care of Nonrheumatic Valvular Heart Disease in Asia and Globally"],"prefix":"10.1161","volume":"15","author":[{"given":"Chaofeng","family":"Niu","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine, Dongzhimen Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, Dongzhimen 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