{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:32:55Z","timestamp":1792186375933,"version":"4.4.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, has demonstrated greater receptor selectivity and fewer adverse effects compared with older mineralocorticoid receptor antagonists. Clinical trials support its efficacy in reducing kidney disease progression, cardiovascular events, and heart failure outcomes across various patient populations; however, anecdotally, the drug appears infrequently used in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">A serial, cross\u2010sectional analysis of IQVIA's National Prescription Audit, which covers &gt;70% of US outpatient prescription activity, was conducted from July 2021 to December 2024 to examine finerenone prescribing trends, focusing on cardiologists and nephrologists. For added context, prescription rates of finerenone were compared with those of 2 other medications with related mechanisms or indications commonly used in cardiovascular\u2010kidney\u2010metabolic syndrome, spironolactone and empagliflozin. Prescribing trends were correlated with total search activity using Google Trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We found that finerenone was prescribed at a rate of 30\u2009180 prescriptions\/month in December 2022, increasing to 45\u2009420 prescriptions\/month in December 2023, and to 60\u2009756 prescriptions\/month in December 2024. This modest increase correlated with changes in Google search activity, with mild inflections after the release of major clinical trial data. The ratio of total prescriptions from nephrologists (15.81 prescriptions per nephrologist)\/cardiologists (0.70 prescriptions per cardiologist) in 2024 was \u224823:1. The proportion of finerenone prescriptions to other cardiovascular\u2010kidney\u2010metabolic therapies remained low, with finerenone prescriptions numerically representing 3.0% of empagliflozin prescriptions and 2.6% of spironolactone prescriptions in 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The adoption of finerenone has been modest, especially among cardiologists compared with nephrologists, and lags behind other cardiovascular\u2010kidney\u2010metabolic therapies. However, recent trends show an upward shift in its use that correlates with public interest related to clinical trial results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046837","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:54:12Z","timestamp":1781006052000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Finerenone Prescriptions in the United States (2021\u20132024) by Physician Specialty: Analysis of Use and Potential in the Cardiovascular\u2010Kidney\u2010Metabolic Space"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9269-7377","authenticated-orcid":false,"given":"Yara","family":"Jelwan","sequence":"first","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Cardiovascular Disease Prevention","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Cao","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Cardiovascular Disease Prevention","place":["Baltimore, USA"]},{"name":"Johns Hopkins Bloomberg School of Public Health","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6356-1524","authenticated-orcid":false,"given":"Zhiqi","family":"Yao","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Cardiovascular Disease Prevention","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4313-3071","authenticated-orcid":false,"given":"Semenawit","family":"Burka","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Cardiovascular Disease Prevention","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-9188","authenticated-orcid":false,"given":"John","family":"Erhabor","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Cardiovascular Disease Prevention","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4152-0366","authenticated-orcid":false,"given":"Phillip","family":"Berning","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Cardiovascular Disease Prevention","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9483-3510","authenticated-orcid":false,"given":"Omar","family":"Dzaye","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-9683","authenticated-orcid":false,"given":"Michael","family":"Blaha","sequence":"additional","affiliation":[{"name":"Johns Hopkins Ciccarone Center for Cardiovascular Disease Prevention","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000664"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318093"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001184"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.102344"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-020-01399-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19213"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae346"},{"key":"e_1_3_2_8_3","doi-asserted-by":"publisher","unstructured":"Erratum in: Clin Kidney J. 2025 May 16;18(5):sfaf145. 10.1093\/ckj\/sfaf145. 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