{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:44Z","timestamp":1789715024098,"version":"4.0.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Polypharmacy, commonly defined as the concurrent use of \u22655 medications, is associated with adverse outcomes, but comprehensive data on its prevalence and temporal trends in patients with atrial fibrillation (AF) are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a nationwide retrospective cohort study using FinACAF (Finnish AntiCoagulation in Atrial Fibrillation) cohort, including all patients with incident AF between 2007 and 2018. Data were retrieved from national health care and prescription registers, covering all levels of care. Medication use was assessed within 120\u2009days before and after AF diagnosis. Polypharmacy was defined as the use of \u22655 medications. Temporal trends and associations between baseline characteristics and drug count were analyzed using linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 229\u2009565 patients with incident AF (mean age 72.7\u2009years, SD 13.2; 50% women), the mean number of medications after diagnosis was 6.0 (SD 3.9). Overall, 63.1% of patients were exposed to polypharmacy, and 17.7% used \u226510 medications. Polypharmacy was more common among older patients and those with comorbidities, especially hypertension and diabetes. From 2007 to 2018, the mean number of drugs increased modestly (from 5.5 to 6.2,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). The most pronounced increases were seen in anticoagulant and cardiovascular drug use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Polypharmacy is highly prevalent among patients with AF in Finland and has increased over time. These findings underscore the need for holistic, patient\u2010centered management strategies to optimize outcomes in this multimorbid population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.046930","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:24:06Z","timestamp":1774430646000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Polypharmacy Among Patients With Atrial Fibrillation: A Report From the Finnish AntiCoagulation in Atrial Fibrillation Nationwide Cohort Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3441-5078","authenticated-orcid":false,"given":"Niklas","family":"Kiuru","sequence":"first","affiliation":[{"name":"Turku University","place":["Turku, Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanni","family":"Reinil\u00e4","sequence":"additional","affiliation":[{"name":"Turku University Hospital","place":["Turku, Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2382-7962","authenticated-orcid":false,"given":"Ville","family":"Lang\u00e9n","sequence":"additional","affiliation":[{"name":"Turku University Hospital and University of Turku","place":["Turku, Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3398-4283","authenticated-orcid":false,"given":"Jussi","family":"Jaakkola","sequence":"additional","affiliation":[{"name":"Turku University Hospital, and University of Turku","place":["Turku, Finland"]},{"name":"Satakunta Central Hospital","place":["Pori, Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0193-568X","authenticated-orcid":false,"given":"K. 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