{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:18:46Z","timestamp":1789683526549,"version":"4.0.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">To evaluate the association between tirzepatide use and 1\u2010year risk of major adverse cardiovascular events in patients with type 2 diabetes and atherosclerotic cardiovascular disease, compared with GLP\u20101 (glucagon\u2010like peptide\u20101) receptor agonists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a retrospective, propensity score\u2010matched cohort study using the TriNetX network. A total of 16\u2009402 patients with type 2 diabetes and atherosclerotic cardiovascular disease initiating tirzepatide or GLP\u20101 receptor agonists between January 1, 2022, and March 31, 2025 were matched 1:1. The primary outcome was 1\u2010year major adverse cardiovascular events; secondary outcomes included all\u2010cause mortality, acute myocardial infarction, major adverse limb events, and tissue plasminogen activator use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Tirzepatide was associated with a lower risk of major adverse cardiovascular events (hazard ratio [HR], 0.75 [95% CI, 0.63\u20130.91]) and reduced risks of all\u2010cause mortality (HR, 0.69 [95% CI, 0.53\u20130.90]), major adverse limb events (HR, 0.59 [95% CI, 0.39\u20130.88]), and acute myocardial infarction (HR, 0.70 [95% CI, 0.53\u20130.93]), compared with GLP\u20101 receptor agonists. Results were robust across subgroups and sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among patients with type 2 diabetes and atherosclerotic cardiovascular disease, tirzepatide was associated with a significantly reduced 1\u2010year risk of major adverse cardiovascular events and other cardiovascular outcomes compared with GLP\u20101 receptor agonists. These findings support the cardiometabolic potential of tirzepatide, warranting further prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047018","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:52:50Z","timestamp":1784285570000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Cardiovascular Outcomes of Tirzepatide and Glucagon\u2010Like Peptide\u20101 Receptor Agonists in Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-1909","authenticated-orcid":false,"given":"Jheng\u2010Yan","family":"Wu","sequence":"first","affiliation":[{"name":"Chi Mei Medical Centre","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng\u2010Wei","family":"Lee","sequence":"additional","affiliation":[{"name":"Chi Mei Medical Centre, Chiali","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Li","family":"Kao","sequence":"additional","affiliation":[{"name":"I\u2010Shou University","place":["Kaohsiung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Chuan","family":"Hung","sequence":"additional","affiliation":[{"name":"Chi Mei Medical Centre","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung","family":"Yu","sequence":"additional","affiliation":[{"name":"National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1723-828X","authenticated-orcid":false,"given":"Yu\u2010Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Chi Mei Medical Centre","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","volume-title":"IDF Diabetes Atlas","author":"Magliano DJ","year":"2021","unstructured":"Magliano DJ, Boyko EJ; IDF Diabetes Atlas Committee . 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