{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:09:04Z","timestamp":1789553344417,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Survival following lung transplant (LT) surgery presents an ongoing challenge, and adverse LT outcomes are linked to cardiac arrhythmias. Current guidelines indicate that the role of \u03b2\u2010adrenergic suppression (BAS) after LT remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This retrospective observational study included adult patients who underwent LT at the University of Florida between 2016 and 2021. Their pre\u2010 and post\u2010LT antiarrhythmic medication use was correlated with long\u2010term survival after a 10\u2010day post\u2010LT blanking window.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The LT recipients (N=299) had a mean age of 60\u00b111\u2009years, 45% were women, and mean body mass index was 26\u00b16\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Available mean follow\u2010up was 4.5\u00b11.9\u2009years. The primary analysis included 299 patients, of whom 209 (70%) were prescribed BAS. Prescription of BAS after LT correlated with prolonged survival, even after adjusting for potential confounders (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.008). A comparable survival benefit was observed in patients who continued BAS from pre\u2010LT to those who were newly initiated on BAS after LT, relative to patients not receiving BAS (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.03 and\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.03, respectively). No survival benefit was observed for other classes of antiarrhythmic drugs used after LT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">This large, retrospective, single\u2010center study identified a correlation between BAS prescriptions and prolonged survival following LT. This association applied to both patients initiating BAS after transplant and those continuing preexisting BAS therapy. These findings underscore the promise of BAS in this population, and further prospective studies are warranted to confirm the beneficial role of BAS after LT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047053","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:55:22Z","timestamp":1781006122000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Survival With \u03b2\u2010Adrenergic Suppression After Lung Transplantation"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0606-4278","authenticated-orcid":false,"given":"Thomas","family":"Konecny","sequence":"first","affiliation":[{"name":"University of Florida, College of Medicine","place":["Gainesville, USA"]},{"name":"Malcolm Randall Veteran Affairs Medical Center","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus K.","family":"Khalily","sequence":"additional","affiliation":[{"name":"University of Florida, College of Medicine","place":["Gainesville, USA"]},{"name":"Malcolm Randall Veteran Affairs Medical Center","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Nusbickel","sequence":"additional","affiliation":[{"name":"University of Florida, College of Medicine","place":["Gainesville, USA"]},{"name":"Malcolm Randall Veteran Affairs Medical Center","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen","family":"Konecny","sequence":"additional","affiliation":[{"name":"Oak Hall School","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Anair","sequence":"additional","affiliation":[{"name":"University of Florida, College of Medicine","place":["Gainesville, USA"]},{"name":"Malcolm Randall Veteran Affairs Medical Center","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan S.","family":"Petty","sequence":"additional","affiliation":[{"name":"University of Florida, College of Medicine","place":["Gainesville, USA"]},{"name":"Malcolm Randall Veteran Affairs Medical Center","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Beck\u2010Fernandez","sequence":"additional","affiliation":[{"name":"University of Florida, College of Medicine","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3619-9010","authenticated-orcid":false,"given":"Zubin","family":"Agarwal","sequence":"additional","affiliation":[{"name":"University of Florida, College of Medicine","place":["Gainesville, USA"]},{"name":"Malcolm Randall Veteran Affairs Medical Center","place":["Gainesville, USA"]},{"name":"Kettering Health, Wright State University College of Medicine","place":["Dayton, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Shahmohammadi","sequence":"additional","affiliation":[{"name":"University of Florida, College of Medicine","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5125-8808","authenticated-orcid":false,"given":"Amir","family":"Emtiazjoo","sequence":"additional","affiliation":[{"name":"University of Florida, College of Medicine","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","unstructured":"Curtin S Tejada\u2010Vera B Bastian B. 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