{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:09:50Z","timestamp":1789553390503,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Guideline\u2010directed medical therapy (GDMT) reduces morbidity and mortality in heart failure with reduced ejection fraction, yet it remains underused. Patient\u2010activation interventions, including checklist\u2010based decision support, have shown improvement in GDMT optimization, and iterative refinement of such tools may enhance their impact. We analyzed recorded clinician\u2013patient encounters, in which a checklist\u2010based activation tool was used, to identify barriers to GDMT optimization and opportunities to enhance decision support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This was a secondary analysis of transcript data from the POCKET\u2010COST\u2010HF (Integrating Cost Into Shared Decision\u2010Making for Heart Failure With Reduced Ejection Fraction) trial, which implemented a checklist\u2010based tool focused on prescription price transparency. Patients and clinicians at 2 academic health centers received adapted versions of the EPIC\u2010HF (Electronically Delivered Patient\u2010Activation Tool for Intensification of Medications for Chronic Heart Failure With Reduced Ejection Fraction) checklist outlining approved medications and target doses for HFrEF. Encounters were audio recorded and transcribed and underwent content analysis to identify barriers and opportunities for checklist improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Encounters between 247 patients with heart failure with reduced ejection fraction (mean age 62.9, 29.5% female, 26.3% Black) and 39 clinicians were included. Baseline GDMT use was high (95% beta blockers, 81% angiotensin\u2010converting enzyme inhibitors\/angiotensin receptor blockers\/angiotensin receptor\u2010neprilysin inhibitors, 63% mineralocorticoid receptor antagonists, and 43% SGLT2 [sodium\u2010glucose cotransporter 2] inhibitors). The checklist was referenced in 48.6% of encounters, and GDMT optimization discussed in 75.7%. Barriers to optimization were identified in 61.5% of encounters, the most common (74.3%) being medical (eg, hypotension). Nonmedical barriers included medication cost (29.6%) and resistance from patients or clinicians (13.8%), often reflecting clinical inertia or desire to minimize medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Nonmedical barriers to GDMT optimization may be addressed by decision\u2010support tools such as checklists. These data suggest that attention to cost, clinical inertia, and desire to minimize medications should be prioritized in future iterations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047062","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:52:48Z","timestamp":1781005968000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Barriers to Optimization of Medical Therapy and the Role of Checklist\u2010Based Decision Support in Heart Failure"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5359-1507","authenticated-orcid":false,"given":"Brett M.","family":"Montelaro","sequence":"first","affiliation":[{"name":"Emory University School of Medicine","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Woods","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace D.","family":"Speight","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1730-0402","authenticated-orcid":false,"given":"Eisha P.","family":"Udeshi","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea R.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1491-1131","authenticated-orcid":false,"given":"Michael A.","family":"Burke","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4104-9965","authenticated-orcid":false,"given":"Jamie","family":"Diamond","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["Atlanta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-3707","authenticated-orcid":false,"given":"Alanna A.","family":"Morris","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["Atlanta, USA"]},{"name":"Bayer US LLC","place":["Whippany, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1807-3465","authenticated-orcid":false,"given":"Engels N.","family":"Obi","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc.","place":["Rahway, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andra S.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc.","place":["Rahway, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Tiedeken","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc.","place":["Rahway, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4415-3861","authenticated-orcid":false,"given":"Neal W.","family":"Dickert","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine","place":["Atlanta, 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