{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:05:13Z","timestamp":1792209913035,"version":"4.4.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Advances in diagnosis and disease awareness have led to increased prevalence and incidence of transthyretin amyloid cardiomyopathy (ATTR\u2010CM), but current US population\u2010based epidemiologic data are lacking. This study aimed to estimate temporal trends and current prevalence and incidence of ATTR\u2010CM in the United States and to describe patient characteristics and the clinical burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Data from the US Merative MarketScan Medicare Database (2010\u20132021) and the IQVIA PharMetrics Plus (2016\u20132023) claims database were assessed. An algorithm using codes for diagnoses and clinical drugs was used to identify patients with ATTR\u2010CM among individuals \u226518\u2009years old. Incidence, prevalence, demographics, comorbidities, medication use, and clinical encounters were assessed annually in cross\u2010sectional cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">The incidence and prevalence of ATTR\u2010CM became higher over time, particularly in men and older age groups. The incidence per 100\u2009000 person\u2010years was 44.3 (95% CI, 39.4\u201349.2) in 2021 for the Medicare Database (individuals aged \u226565\u2009years) and 5.4 (95% CI, 5.0\u20135.8) in 2022 for PharMetrics Plus (individuals aged \u226518\u2009years); the prevalence per 100\u2009000 individuals was 95.8 (95% CI, 89.2\u2013102.4) in 2022 in the Medicare Database and 11.3 (95% CI, 10.8\u201311.8) in 2023 in PharMetrics Plus. The number of comorbidities and medication use in the year before diagnosis increased over time; the number of clinical encounters in the year before diagnosis was relatively stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The incidence and prevalence of ATTR\u2010CM diagnoses have increased in the United States from 2010 to 2023, and the clinical burden among newly diagnosed individuals has become more complex.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047135","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:40:12Z","timestamp":1782211212000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Temporal Trends in Incidence and Prevalence of Transthyretin Amyloid Cardiomyopathy in the United States"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4024-3691","authenticated-orcid":false,"given":"Kevin M.","family":"Alexander","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel R.","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine","place":["Indianapolis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmi","family":"Mathisen","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S","place":["S\u00f8borg, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidsel Gamborg","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S","place":["S\u00f8borg, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Tvistholm","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S","place":["S\u00f8borg, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-5008","authenticated-orcid":false,"given":"Mathew S.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center, New York Presbyterian Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006075"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.200"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404852"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023895"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.005407"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2021.05.004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2020.08.558"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13961"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5493"},{"key":"e_1_3_2_11_2","unstructured":"Orphanet . Wild type ATTR amyloidosis: 2021. Accessed January 24 2024. https:\/\/www.orpha.net\/consor\/cgi\u2010bin\/Disease_Search.php?lng=EN&data_id=21955&Disease_Disease_Search_diseaseGroup=attr&Disease_Disease_Search_diseaseType=Pat&Disease(s)\/group%20of%20diseases=Wild\u2010type\u2010ATTR\u2010amyloidosis&title=Wild%20type%20ATTR%20amyloidosis&search=Disease_Search_Simple."},{"key":"e_1_3_2_12_2","unstructured":"Orphanet . Prevalence of rare diseases: Bibliographic data: 2023. Accessed January 24 2024. http:\/\/www.orpha.net\/orphacom\/cahiers\/docs\/GB\/Prevalence_of_rare_diseases_by_alphabetical_list.pdf."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-052918-020140"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890701842988"},{"key":"e_1_3_2_15_2","unstructured":"R Core Team . R: A Language and Environment for Statistical Computing: 2023. https:\/\/www.R\u2010project.org."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2024.2398735"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-022-02114-y"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-019-0142-5"},{"key":"e_1_3_2_19_2","unstructured":"American Heart Association . Transthyretin amyloid cardiomyopathy (ATTR\u2010CM). Last reviewed May 29 2024. Accessed October 17 2024. https:\/\/www.heart.org\/en\/health\u2010topics\/cardiomyopathy\/what\u2010is\u2010cardiomyopathy\u2010in\u2010adults\/transthyretin\u2010amyloid\u2010cardiomyopathy\u2010attr\u2010cm."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2024-324625"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2024.11.019"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.022"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.047135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:41:16Z","timestamp":1787719276000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.047135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":21,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7,7]]}},"alternative-id":["10.1161\/JAHA.125.047135"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.047135","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"2025-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e047135"}}