{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:09:54Z","timestamp":1789553394133,"version":"build-2803163510"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The optimal antithrombotic regimen for peripheral artery disease, balancing thromboembolic and bleeding risks, remains uncertain. This study aimed to compare the efficacy and safety of antithrombotic regimens in patients with peripheral artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We reviewed randomized controlled trials evaluating antithrombotic therapies for peripheral artery disease, including aspirin, P2Y12 inhibitors, cilostazol, and rivaroxaban. The primary outcome was major adverse cardiac events, defined as a composite of cardiovascular death, myocardial infarction, and stroke. The secondary outcomes included major adverse limb events, defined as a composite of acute limb ischemia, revascularization, and amputation. The safety outcome was major bleeding, primarily assessed using the Thrombolysis in Myocardial Infarction criteria. We performed a network meta\u2010analysis to compare antithrombotic regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Seventeen randomized controlled trials involving 44\u2009532 participants were included. Compared with aspirin monotherapy, the following were associated with lower risks of major adverse cardiac events: clopidogrel, 75 mg\/d, plus cilostazol, 200 mg\/d (hazard ratio [HR], 0.37 [95% CI, 0.20\u20130.72]), clopidogrel, 75 mg\/d, monotherapy (HR, 0.80 [95% CI, 0.67\u20130.96]), aspirin plus low\u2010dose rivaroxaban, 2.5 mg twice daily (HR, 0.81 [95% CI, 0.72\u20130.92]), and aspirin plus ticagrelor, 60 to 90 mg twice daily (HR, 0.81 [95% CI, 0.69\u20130.96]). Aspirin plus rivaroxaban or ticagrelor showed a lower risk of major adverse limb events compared with aspirin alone. Rivaroxaban monotherapy, 5 mg twice daily, and aspirin plus rivaroxaban or clopidogrel were associated with a higher risk of major bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Clopidogrel plus cilostazol or clopidogrel monotherapy might be a balanced strategy in patients with peripheral artery disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047301","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:17:20Z","timestamp":1781525840000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Optimal Antithrombotic Therapy for Peripheral Artery Disease: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5934-6651","authenticated-orcid":false,"given":"Yuriko","family":"Hiruma","sequence":"first","affiliation":[{"name":"United States Naval Hospital Okinawa","place":["Okinawa, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-0329","authenticated-orcid":false,"given":"Atsuyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1786-0176","authenticated-orcid":false,"given":"Tadao","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Juntendo University Graduate School of Medicine","place":["Tokyo, 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