{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:53:18Z","timestamp":1791355998318,"version":"4.3.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with severe aortic stenosis with very low resting aortic valve mean gradient (MG) are underrepresented in transcatheter aortic valve replacement (TAVR) studies. We investigated the association of resting aortic valve MG with post\u2010TAVR outcomes in a large nationwide cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We included patients from the Society of Thoracic Surgeons\/American College of Cardiology Transcatheter Valve Therapy Registry with a self\u2010expanding Evolut TAVR (until December 2022) and eligible for 1\u2010year follow\u2010up without prior balloon aortic valvuloplasty, TAVR, or surgical aortic valve replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 80\u2009429 patients (mean age, 80.7\u00b17.9; women, 53.9%; high\/extreme surgery risk, 51.2%) stratified into 6 echocardiographic resting aortic valve MG groups (10\u2013&lt;20, 20\u2013&lt;25, 25\u2013&lt;30, 30\u2013&lt;35, 35\u2013&lt;40, \u226540\u2009mmHg), 1\u2009year, all\u2010cause mortality increased progressively across decreasing MG subgroups (from 9.3%, \u226540\u2009mmHg to 20.9%, 10\u2013&lt;20\u2009mmHg;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001; 10.8% entire cohort), as did hospital readmission. Kansas City Cardiomyopathy Questionnaire scores increased progressively across increasing MG subgroups (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001 at all time points). The Valve Academic Research Consortium 3 Kansas City Cardiomyopathy Questionnaire ordinal outcome improved substantially\/moderately for all subgroups (1\u2009year \u226552% patients). After multiple imputation for missing covariate data, Cox regression adjusting for clinically relevant baseline factors demonstrated a significant association between baseline MG and 1\u2010year mortality (hazard ratio, 0.93 [95% CI, 0.91\u20130.94];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Baseline aortic valve MG is an important predictor of 1\u2010year all\u2010cause mortality in patients with severe aortic stenosis undergoing TAVR. Most patients undergoing TAVR had considerably improved quality\u2010of\u2010life assessments regardless of resting MG. Additional studies should elucidate mechanisms associated with MG\u2013mortality risk and whether improved patient selection can further improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047319","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:24:06Z","timestamp":1788150246000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Aortic Valve Mean Gradient and TAVR Outcomes: A Perspective From a Nationwide Registry"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-4956","authenticated-orcid":false,"given":"Matthew J.","family":"Czarny","sequence":"first","affiliation":[{"name":"Johns Hopkins University","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeve","family":"Jones\u2010O'Connor","sequence":"additional","affiliation":[{"name":"Johns Hopkins University","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0516-9855","authenticated-orcid":false,"given":"Rani K.","family":"Hasan","sequence":"additional","affiliation":[{"name":"Johns Hopkins University","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Rahman","sequence":"additional","affiliation":[{"name":"Johns Hopkins University","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8291-1251","authenticated-orcid":false,"given":"Hamza","family":"Aziz","sequence":"additional","affiliation":[{"name":"Johns Hopkins University","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9579-2765","authenticated-orcid":false,"given":"Michael P.","family":"Robich","sequence":"additional","affiliation":[{"name":"Johns Hopkins University","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Haugan","sequence":"additional","affiliation":[{"name":"Structural Heart and Aortic","place":["Minneapolis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-5420","authenticated-orcid":false,"given":"Jon R.","family":"Resar","sequence":"additional","affiliation":[{"name":"Johns Hopkins University","place":["Baltimore, 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