{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:39Z","timestamp":1789715019309,"version":"4.0.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The frequency of residual angina and its impact on health status and death following anatomic complete revascularization in symptomatic patients with chronic coronary disease are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Data were analyzed from ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) trial participants randomized to invasive management with baseline angina (Seattle Angina Questionnaire Angina Frequency score &lt;100), no prior coronary artery bypass graft surgery, and anatomic complete revascularization within 90\u2009days of randomization. The primary outcome was frequency of residual angina after revascularization, defined as a Seattle Angina Questionnaire Angina Frequency score &lt;100 within 6\u2009months of randomization. Secondary outcomes included 6\u2010month health status and medication use and 5\u2010year all\u2010cause and cardiovascular death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 2588 participants randomized to invasive management, 1442 (56%) had baseline angina and no prior coronary artery bypass graft surgery; 1034 underwent revascularization within 90\u2009days, and 436 achieved anatomic complete revascularization. Of these, 184 (42.2%) had residual angina within 6 months. Baseline characteristics were similar between those with and without residual angina. Percutaneous coronary intervention was more common than coronary artery bypass graft surgery in those with residual angina (88% versus 80%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.03). At 6 months, residual angina participants reported lower quality of life (Seattle Angina Questionnaire Quality of Life: 70\u00b120 versus 83\u00b120,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), greater physical limitation (Seattle Angina Questionnaire Physical Limitation: 84\u00b120 versus 95\u00b111,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), more dyspnea (Rose Dyspnea Scale score: 1\u00b11.3 versus 0.4\u00b10.8,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), and more antianginal medication use (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.006). Five\u2010year all\u2010cause and cardiovascular death did not differ significantly between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Residual angina is common (&gt;40%) following anatomic complete revascularization for chronic coronary disease and is associated with reduced quality of life and greater antianginal medication use but no increase in death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">Unique Identifier: NCT01471522.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047355","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:11:26Z","timestamp":1778757086000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Residual Angina Following Complete Revascularization in the ISCHEMIA Trial: Frequency, Clinical Characteristics, Health Status, and Cardiovascular Outcomes"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9821-0329","authenticated-orcid":false,"given":"Ayesha","family":"Singh","sequence":"first","affiliation":[{"name":"Keck School of Medicine, University of Southern California","place":["Los Angeles, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0930-9747","authenticated-orcid":false,"given":"David L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, University of 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