{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:38:04Z","timestamp":1792647484881,"version":"4.5.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Components of arterial stiffness (structural stiffness from aging and load\u2010dependent stiffness from high blood pressure [BP]) are markers for cardiovascular disease risk. We evaluated relationships between polygenic risk scores (PRSs) for BP and arterial stiffness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Participants (n=5804) are from MESA (Multi\u2010Ethnic Study of Atherosclerosis) with measures of carotid ultrasound and genomic DNA. Carotid pulse wave velocity (PWV) was calculated from carotid ultrasound. Structural stiffness was calculated by adjusting carotid PWV to a 120\/80\u2009mm\u2009Hg BP with participant\u2010specific models. Load\u2010dependent stiffness was the difference of total and structural stiffness. BP PRSs were derived from genome\u2010wide associations. Associations were assessed with multivariable\u2010adjusted regression models. Mendelian randomization was performed with 2\u2010stage least squares.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Participants were aged 62.8\u00b110.3\u2009years. Systolic BP (SBP) was 133.5\u00b120.5\u2009mm\u2009Hg, diastolic BP (DBP) was 74.27\u00b110.28\u2009mm\u2009Hg, and pulse pressure was 59.22\u00b116.17\u2009mm\u2009Hg. Total carotid PWV was associated with the SBP PRS (\u03b2=0.10\u00b10.02,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =5.25E\u201008) and the DBP PRS (\u03b2: 0.08\u00b10.02,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =7.26E\u201007) but not pulse pressure PRS (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.05). Load\u2010dependent carotid PWV was associated with the SBP PRS (\u03b2=0.09\u00b10.01,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =7.93\u00d710\n                      <jats:sup>\u221230<\/jats:sup>\n                      ), the DBP PRS (\u03b2=0.09\u00b10.01,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =4.92\u00d710\n                      <jats:sup>\u221234<\/jats:sup>\n                      ) and the pulse pressure PRS (\u03b2=0.03\u00b10.01,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =8.18\u00d710\n                      <jats:sup>\u22125<\/jats:sup>\n                      ). Structural carotid PWV was not associated with any BP PRSs. With Mendelian randomization, SBP and DBP showed significant independent positive effects on load\u2010dependent stiffness (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001); only SBP was significant for total carotid PWV after accounting for DBP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">There are key differences in the genetic underpinnings of the mechanistic components of arterial stiffness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047424","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:56:24Z","timestamp":1791633384000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Polygenic Determinants of Arterial Stiffness: Implications for Hypertension"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5869-2850","authenticated-orcid":false,"given":"Adam D.","family":"Gepner","sequence":"first","affiliation":[{"name":"William S. Middleton Memorial Veteran's Hospital","place":["Madison, USA"]},{"name":"University of Wisconsin School of Medicine and Public Health","place":["Madison, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-7196","authenticated-orcid":false,"given":"Ryan J.","family":"Pewowaruk","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veteran's Hospital","place":["Madison, USA"]},{"name":"University of Wisconsin School of Medicine and Public Health","place":["Madison, USA"]},{"name":"Ryan Pewowaruk Research Consulting","place":["Madison, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9691-9027","authenticated-orcid":false,"given":"Claudia E.","family":"Korcarz","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veteran's Hospital","place":["Madison, USA"]},{"name":"University of Wisconsin School of Medicine and Public Health","place":["Madison, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-1608","authenticated-orcid":false,"given":"Adriana","family":"Hung","sequence":"additional","affiliation":[{"name":"Nashville VA, Tennessee Valley Healthcare System","place":["Nashville, USA"]},{"name":"Vanderbilt University","place":["Nashville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2756-4370","authenticated-orcid":false,"given":"Kent D.","family":"Taylor","sequence":"additional","affiliation":[{"name":"The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1741-3517","authenticated-orcid":false,"given":"Y.\u2010D. I.","family":"Chen","sequence":"additional","affiliation":[{"name":"The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7616-2119","authenticated-orcid":false,"given":"Alexis C.","family":"Wood","sequence":"additional","affiliation":[{"name":"USDA\/ARS Children's Nutrition Research Center, Baylor College of Medicine","place":["Houston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8822-0651","authenticated-orcid":false,"given":"Jie","family":"Yao","sequence":"additional","affiliation":[{"name":"The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-5068","authenticated-orcid":false,"given":"Xiuqing","family":"Guo","sequence":"additional","affiliation":[{"name":"The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-1723","authenticated-orcid":false,"given":"Jerome I.","family":"Rotter","sequence":"additional","affiliation":[{"name":"The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center","place":["Torrance, 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