{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:59:19Z","timestamp":1785257959948,"version":"3.55.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">To investigate the association of inflammatory markers with the risks of clinical outcomes in patients with acute ischemic stroke and large\u2010vessel occlusion who underwent endovascular thrombectomy treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">A total of 586 patients with acute ischemic stroke and large\u2010vessel occlusion treated with endovascular thrombectomy between May 2017 and February 2025 were enrolled. Patients were stratified into quartiles according to inflammatory markers measured within 24\u2009hours after endovascular thrombectomy, including neutrophil count, neutrophil\u2010to\u2010lymphocyte ratio (NLR), systemic inflammation response index, systemic immune\u2010inflammation index, inflammatory prognostic index, and aggregate index of systemic inflammation. Logistic regression was used to assess associations between these markers and poor functional outcome (modified Rankin Scale score 3\u20136) at 90\u2009days, symptomatic intracranial hemorrhage within 24\u2009hours, and malignant cerebral edema within 5\u2009days. Receiver operating characteristic curves evaluated predictive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      After adjusting for confounders, participants in the highest quartile of each inflammatory marker had significantly higher odds of poor functional recovery (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      for trend\u22640.011), symptomatic intracranial hemorrhage (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      for trend\u22640.010), and malignant cerebral edema (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      for trend\u22640.005), compared with those in the lowest quartile. Receiver operating characteristic curves showed the NLR had the highest discriminative ability to predict poor functional recovery (area under the curve for NLR, 0.692;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), symptomatic intracranial hemorrhage (area under the curve for NLR, 0.740;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) and malignant cerebral edema (area under the curve for NLR, 0.739;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) compared with other inflammatory markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">All inflammatory markers, particularly the NLR, were independently associated with an increased risk of poor functional recovery, symptomatic intracranial hemorrhage, and malignant cerebral edema in patients with acute ischemic stroke and large\u2010vessel occlusion after endovascular thrombectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047436","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:24:05Z","timestamp":1783740245000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Inflammatory Markers With Symptomatic Intracranial Hemorrhage, Malignant Cerebral Edema, and Poor Functional Recovery in Patients With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5518-741X","authenticated-orcid":false,"given":"Suqiu","family":"Huan","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Cheng","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongrong","family":"Sun","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3898-7739","authenticated-orcid":false,"given":"Zhiliang","family":"Guo","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Zheng","sequence":"additional","affiliation":[{"name":"University of New South Wales","place":["Sydney, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hou","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8584-7749","authenticated-orcid":false,"given":"Huaishun","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0988-7698","authenticated-orcid":false,"given":"Yage","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5254-1586","authenticated-orcid":false,"given":"Xiaocui","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-8914","authenticated-orcid":false,"given":"Yongjun","family":"Cao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2674-5505","authenticated-orcid":false,"given":"Guodong","family":"Xiao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6059-0853","authenticated-orcid":false,"given":"Shoujiang","family":"You","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012803"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.034783"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2025-023620"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1359-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02890-y"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1115031"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e31122"},{"key":"e_1_3_2_10_2","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts\u2014rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec R","year":"2001","unstructured":"Zahorec R. Ratio of neutrophil to lymphocyte counts\u2014rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102:5\u201314.","journal-title":"Bratisl Lek Listy"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30057"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2016.17.12.5101"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005886"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10184134"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804656"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016733"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001329"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.64007"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.320224"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70080"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-019-00859-5"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S491753"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-66279-4"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01739-y"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032130"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S365553"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2021.197"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0680-x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221142694"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1361035"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.705949"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-016-0483-x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-023-00690-0"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202503722"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01563-4"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13081"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.852416"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-06799-3"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.036946"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.047436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:08:28Z","timestamp":1785254908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.047436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":38,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,7,21]]}},"alternative-id":["10.1161\/JAHA.125.047436"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.047436","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"2025-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e047436"}}