{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:21:18Z","timestamp":1787721678732,"version":"build-2784847793"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study evaluated the long\u2010term effects of intensive education on functional recovery and quality of life in patients with first\u2010ever mild ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This propensity score\u2013matched cohort study was conducted within the KOSCO (Korean Stroke Cohort for Functioning and Rehabilitation). Four of 9 institutions participated in the educational intervention substudy, recruiting patients between November 2016 and January 2020. Eligible participants were adults aged 19 to 74\u2009years hospitalized within 7\u2009days of a first\u2010ever ischemic stroke, with mild neurological deficits (Korean version of National Institutes of Health Stroke Scale score 1\u20135), who consented to participate in the study. The intervention consisted of 3 structured education sessions delivered over 3\u2009months. Functional and quality\u2010of\u2010life outcomes were assessed at baseline and at multiple intervals up to 48\u2009months. A matched control group was selected from the primary KOSCO cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">After matching, 138 participants were included in each group. Baseline characteristics were well balanced. Over the 48\u2010month follow\u2010up period, the intervention group demonstrated greater improvements in the EuroQol\u20105 Dimension (\u03b2=\u22120.005 [95% CI, \u22120.009 to \u22120.001]), Geriatric Depression Scale\u2013Short Form (\u03b2=0.147 [95% CI, 0.015\u20130.279]), and modified Rankin Scale (\u03b2=11.48 [95% CI, 0.05\u201322.92]), compared with controls. No significant group\u2010by\u2010time interactions were found for other functional measures, including the Functional Independence Measure, Korean version of Modified Barthel Index, Fugl\u2013Meyer Assessment, and Korean Mini\u2010Mental State Examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Structured, intensive, multisession education for patients with first\u2010ever mild ischemic stroke produced favorable long\u2010term effects on quality of life, psychological well\u2010being, and disability, highlighting the value of comprehensive education as part of stroke rehabilitation and secondary prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>REGISTRATION<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/cris.nih.go.kr\">http:\/\/cris.nih.go.kr<\/jats:ext-link>\n                      ; Unique identifier: KCT0003277.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047525","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:24:12Z","timestamp":1783074252000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Effect of Intensive Education in Patients With First\u2010Ever Ischemic Stroke"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3282-1164","authenticated-orcid":false,"given":"Yeong Wook","family":"Kim","sequence":"first","affiliation":[{"name":"Chungnam National University","place":["Daejeon, Republic of 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Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2778-4194","authenticated-orcid":false,"given":"Min Cheol","family":"Joo","sequence":"additional","affiliation":[{"name":"Wonkwang University School of Medicine","place":["Iksan, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0433-4548","authenticated-orcid":false,"given":"So Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Jeju National University Hospital, Jeju National University School of Medicine","place":["Jeju City, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8186-5345","authenticated-orcid":false,"given":"Min\u2010Keun","family":"Song","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School","place":["Gwangju, Republic of 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