{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:31:08Z","timestamp":1793802668227,"version":"4.6.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"\n Background<\/jats:title>\n We examined the relationship between infection\u2010related hospitalization (IRH) and heart failure (HF) in a large clinical health system and assessed whether IRH improved prediction beyond HF risk equations.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We studied 80\u2009880 adults (14\u2009150 with IRH and 66\u2009730 age\u2010 and sex\u2010matched comparators) aged \u226518\u2009years without HF in the Rochester Epidemiology Project from 1\/1\/2005\u201312\/31\/2019. IRH was identified using\n International Classification of Diseases<\/jats:italic>\n (\n ICD<\/jats:italic>\n ) codes. HF incidence was defined as \u22651 HF\u2010related\n ICD<\/jats:italic>\n code. Multivariable Cox models assessed the association between IRH and incident HF. Among 29\u2009219 adults aged 30 to 79\u2009years without baseline cardiovascular disease in the Rochester Epidemiology Project, Harrell's concordance statistic assessed whether IRH improved discrimination of the Predicting Risk of Cardiovascular Disease EVENTs\u2013Heart Failure (PREVENT\u2010HF) equations.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Participants were 53.3% women, 85.6% White individuals, and 95.1% non\u2010Hispanic individuals, with a mean age of 56.0\u00b120.0\u2009years. Median follow\u2010up time was 6.2\u2009years. Among the IRH group, 2729 developed incident HF (2.75\/100 person\u2010years) versus 4854 (1.00\/100 person\u2010years) in the comparator. The multivariable adjusted hazard ratio for incident HF among participants with versus without an IRH was 1.85 (95% CI, 1.76, 1.94). In a separate cohort, incorporating IRH into PREVENT\u2010HF increased the concordance statistic from 0.776 to 0.779 (change, 0.003 [95% CI, 0.001\u20130.004]). The PREVENT\u2010HF risk score underestimated the 10\u2010year risk of HF by up to 9% among participants with an IRH.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n IRH was associated with incident HF but provided negligible change to 10\u2010year HF risk discrimination. However, among individuals with an IRH, incorporating this information meaningfully improved 10\u2010year HF risk prediction. Severe infections may serve as a risk\u2010enhancing factor warranting enhanced preventive measures, particularly in populations where IRH is more common.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.125.047537","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:49:35Z","timestamp":1787226575000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Severe Infections as a Novel Risk\u2010Enhancing Factor for Incident Heart Failure"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-0379","authenticated-orcid":false,"given":"Ryan T.","family":"Demmer","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine and Science","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7112-9061","authenticated-orcid":false,"given":"Brandon R.","family":"Grossardt","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-1859","authenticated-orcid":false,"given":"Sadiya S.","family":"Khan","sequence":"additional","affiliation":[{"name":"Northwestern University","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-0596","authenticated-orcid":false,"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001303"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2410027"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03374-z"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.01.049"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.36628\/ijhf.2022.0030"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812389"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067626"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033877"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.039123"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001307"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.08.012"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys195"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq482"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0306164"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101323"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3862"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3552"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042718-041717"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05918"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1179\/096805106X102246"},{"key":"e_1_3_1_25_2","unstructured":"McDermott KW. Most Frequent Principal Diagnoses for Inpatient Stays in U.S. Hospitals. https:\/\/www.hcup\u2010us.ahrq.gov\/reports\/statbriefs\/sb277\u2010Top\u2010Reasons\u2010Hospital\u2010Stays\u20102018.pdf2021."}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.047537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:18:39Z","timestamp":1793801919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.047537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":24,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1161\/JAHA.125.047537"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.047537","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2025-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e047537"}}