{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:02:37Z","timestamp":1785250957324,"version":"3.55.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Tricuspid transcatheter edge\u2010to\u2010edge repair is an established therapy for high\u2010grade tricuspid regurgitation, but its acute impact on right ventricular (RV) mechanics remains incompletely understood. The aim of the study was to quantify the acute hemodynamic effects of tricuspid transcatheter edge\u2010to\u2010edge repair on RV function using invasive pressure\u2013volume analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Nine patients with severe tricuspid regurgitation (grades III\u2013IV) underwent simultaneous invasive and echocardiographic assessment of RV function. A 7\u2010electrode conductance catheter positioned in the RV continuously recorded pressure\u2013volume signals, calibrated against 3\u2010dimensional echocardiographic RV volumes. Steady\u2010state RV pressure\u2013volume loops and RV echocardiography were obtained before and after the procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Tricuspid transcatheter edge\u2010to\u2010edge repair significantly reduced regurgitant volume. Forward stroke volume increased significantly (41 [34\u201348] versus 51 [43\u201357] mL,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.004), despite unchanged RV afterload and contractility (end\u2010systolic elastance, 0.33 [0.24\u20130.53] versus 0.32 [0.25\u20130.72] mm\u2009Hg\/mL,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.30). Stroke work was preserved. Preload decreased (RV end\u2010diastolic volume, 145 [113\u2013171] versus 131 [104\u2013137] mL,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.01; RV end\u2010diastolic pressure, 9 [6\u201311] versus 7 [4\u20139] mm\u2009Hg,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.03), reflecting substantial RV unloading.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Successful tricuspid transcatheter edge\u2010to\u2010edge repair is accompanied by economization of myocardial work through redirection of blood flow into the pulmonary circulation. Forward stroke volume increased while contractility and stroke work remained unchanged. Preload was significantly reduced, indicating an improved preload reserve.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047560","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:19:03Z","timestamp":1777457943000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Impact of Transcatheter Edge\u2010to\u2010Edge Repair of Tricuspid Regurgitation on Right Ventricular Hemodynamics"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-5175","authenticated-orcid":false,"given":"Jan\u2010Christian","family":"Reil","sequence":"first","affiliation":[{"name":"Ruhr\u2010Universit\u00e4t Bochum, Herz\u2010und Diabetes Zentrum\u2010NRW, Klinik f\u00fcr Allgemeine und Interventionelle Kardiologie","place":["Bad Oeynhausen, 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Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-4082","authenticated-orcid":false,"given":"Anna","family":"Klinke","sequence":"additional","affiliation":[{"name":"Ruhr\u2010Universit\u00e4t Bochum, Herz\u2010und Diabetes Zentrum\u2010NRW, Klinik f\u00fcr Allgemeine und Interventionelle Kardiologie","place":["Bad Oeynhausen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8796-4416","authenticated-orcid":false,"given":"Gert\u2010Hinrich","family":"Reil","sequence":"additional","affiliation":[{"name":"Klinikum Oldenburg","place":["Oldenburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-3048","authenticated-orcid":false,"given":"Kai P.","family":"Friedrichs","sequence":"additional","affiliation":[{"name":"Ruhr\u2010Universit\u00e4t Bochum, Herz\u2010und Diabetes Zentrum\u2010NRW, Klinik f\u00fcr Allgemeine 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