{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:59:27Z","timestamp":1785257967387,"version":"3.55.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Recurrent pericarditis may be mediated through inappropriate activation of the NACHT, leucine\u2010rich repeat, and pyrin domain\u2010containing protein 3 inflammasome. Pharmaceutically manufactured cannabidiol is an oral formulation that inhibits NACHT, leucine\u2010rich repeat, and pyrin domain\u2010containing protein 3 inflammasome activation and development of pericarditis in a preclinical model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This Phase 2, open\u2010label, multicenter trial included adult patients with symptomatic recurrent pericarditis: pericarditis chest pain \u22654 on an 11\u2010point numerical rating scale\u00a0with an elevated C\u2010reactive protein (\u22651 mg\/dL) or at least mild pericardial inflammation on cardiac magnetic resonance imaging. At enrollment, patients were on stable doses of non\u2010steroidal anti\u2010inflammatory drugs, colchicine, and\/or corticosteroids. Cannabidiol was administered during an 8\u2010week treatment period and an optional 18\u2010week extension period when background therapy was tapered and discontinued. The primary efficacy end point was change in patient\u2010reported pericarditis pain. Secondary end points included normalization of C\u2010reactive protein and percentage of patients with recurrences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 27 patients (18 women, mean age 53\u2009years), baseline maximal numerical rating scale pain score was 5.8\u00b11.7, and 10 patients had elevated C\u2010reactive protein. At Week 8, maximal numerical rating scale pain score was 2.1\u00b11.8, and median time to numerical rating scale score \u22642 was 5\u2009days. Among the 10 patients with baseline C\u2010reactive protein elevation, C\u2010reactive protein was normal at Week 8 in 8 patients (80%). During the extension period, 17 (71%) of 24 patients remained free of pericarditis recurrence. A serious adverse event leading to cannabidiol discontinuation occurred in 1 patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In symptomatic patients with recurrent pericarditis, pharmaceutically manufactured cannabidiol appears safe and associated with reductions in pericarditis pain and systemic inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique Identifier: NCT05494788.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047605","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:23:41Z","timestamp":1783740221000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Pharmaceutically Manufactured Cannabidiol in Recurrent Pericarditis: A Phase II Clinical Trial"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9821-1225","authenticated-orcid":false,"given":"Sushil Allen","family":"Luis","sequence":"first","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-8369","authenticated-orcid":false,"given":"Allan L.","family":"Klein","sequence":"additional","affiliation":[{"name":"Heart, Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0794-3306","authenticated-orcid":false,"given":"Paul C.","family":"Cremer","sequence":"additional","affiliation":[{"name":"Heart, Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]},{"name":"Bluhm Cardiovascular Institute, Northwestern University","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1930-785X","authenticated-orcid":false,"given":"Antonio","family":"Abbate","sequence":"additional","affiliation":[{"name":"University of Virginia","place":["Charlottesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3796-866X","authenticated-orcid":false,"given":"Jonathan R.","family":"Salik","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-258X","authenticated-orcid":false,"given":"Georgia K.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University Health System","place":["Richmond, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5385-9228","authenticated-orcid":false,"given":"Syed Waqas","family":"Haider","sequence":"additional","affiliation":[{"name":"MedStar Georgetown University Hospital","place":["Washington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy E.","family":"Hagerty","sequence":"additional","affiliation":[{"name":"University of Vermont Medical Center, Larner College of Medicine","place":["Burlington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lin","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital\/Allina Health","place":["Minneapolis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0896-9376","authenticated-orcid":false,"given":"Thomas E.","family":"Waggoner","sequence":"additional","affiliation":[{"name":"US Heart & Vascular, Tucson Medical Center","place":["Tucson, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9668-4368","authenticated-orcid":false,"given":"Stephen J.","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Monash University","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget\u2010Anne","family":"Kirwan","sequence":"additional","affiliation":[{"name":"SOCAR Research SA","place":["Nyon, Switzerland"]},{"name":"London School of Hygiene and Tropical Medicine","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6182-3291","authenticated-orcid":false,"given":"Kelly A. D.","family":"Narine","sequence":"additional","affiliation":[{"name":"Cardiol Therapeutics Inc.","place":["Oakville, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea B.","family":"Parker","sequence":"additional","affiliation":[{"name":"Cardiol Therapeutics Inc.","place":["Oakville, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hamer","sequence":"additional","affiliation":[{"name":"Cardiol Therapeutics Inc.","place":["Oakville, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.12935"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018950"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.11.018"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.05.023"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf192"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2022.2584"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2020.11.016"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab452"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.785"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28165980"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29020473"},{"key":"e_1_3_2_13_2","first-page":"e169","article-title":"Protective effects of cannabidiol in a mouse model of acute pericarditis","volume":"131","author":"Martinez Naya N","year":"2022","unstructured":"Martinez Naya N, Nirar AH, Kim MM, Mauro AG, Mezzaroma E, Narayan P, Hamer A, Bolton J, Abbate A, Toldo S. 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