{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:20:23Z","timestamp":1787721623395,"version":"build-2784847793"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Outcomes &gt;2\u2009years after transcatheter aortic valve replacement (TAVR) for bicuspid aortic valves (BAV) are scarce, and differences between balloon\u2010expandable transcatheter heart valves (THVs) and self\u2010expandable (SE\u2010THVs) are not yet well established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study aims to report midterm outcomes after TAVR in patients with BAV and includes 92 patients undergoing TAVR for BAV stenosis at the University Hospital Cologne between 2018 and 2023. The primary outcomes were all\u2010cause death, cardiovascular death, and stroke over a mean follow\u2010up of 2.9\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 92 consecutive patients undergoing TAVR for BAV stenosis (median age: 78.8\u2009years), the incidence of all\u2010cause death, cardiovascular death, and stroke was 26.1%, 18.5%, and 14.1%, respectively, at 2.9\u2009years, with no differences between balloon\u2010expandable THVs and SE\u2010THVs. Pacemaker implantation tended to be more frequent in the SE\u2010THV group. Periprocedural complications were rare, as reflected by a high Valve Academic Research Consortium\u20103 technical success rate of 96.7%. Postprocedural transvalvular gradients were favorable, with SE\u2010THV showing lower values than balloon\u2010expandable THV (8.0 versus 10.5\u2009mm\u2009Hg,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.007). Moderate or severe paravalvular regurgitation was uncommon, with no differences between groups, although a trend toward more relevant paravalvular regurgitation with SE\u2010THV was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">TAVR for BAV is feasible with both SE\u2010THV and balloon\u2010expandable \u2010THV, achieving high technical success and low complication rates. Hemodynamic differences were observed, but mortality and stroke did not differ significantly between groups. Overall outcomes remain suboptimal, highlighting the need for randomized trials comparing valve types and TAVR with surgery for patients with BAV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047634","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:34:56Z","timestamp":1782210896000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Midterm Clinical and Echocardiographic Outcomes After Transcatheter Aortic Valve Replacement in Patients With Severe Bicuspid Aortic Valve Stenosis"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5779-7549","authenticated-orcid":false,"given":"Stephan","family":"Nienaber","sequence":"first","affiliation":[{"name":"University of Cologne","place":["Cologne, 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