{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:17:21Z","timestamp":1788329841314,"version":"build-2803163510"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Neurodevelopmental impairment is common in both prematurity and congenital heart disease (CHD). Preterm infants with CHD may have a \u201cdouble hit,\u201d with worse neurodevelopmental impairments than seen in prematurity or CHD alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This single\u2010center retrospective cohort study included children with CHD who underwent cardiac surgery in infancy (2007\u20132020) and completed neurodevelopmental testing. Using the Bayley Scales of Infant and Toddler Development, Third Edition, we assessed cognitive, language, and motor outcomes. Patients were stratified by gestational age: extremely\/very\/moderately preterm (\u226433\u2009weeks), late\u2010preterm (34\u201336\u2009weeks), early\u2010term (37\u201338\u2009weeks), or term\/postterm (\u226539\u2009weeks). Multivariable linear regression was used to model Bayley scores, adjusting for demographic, medical, and surgical covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 1350 infants who underwent cardiac surgery, 513 (38%) completed Bayley scale assessment at median age 28\u2009months (interquartile range, 19\u201334). 448 (87%) were full term and 65 (13%) preterm. After multivariable adjustment, gestational age remained a significant independent predictor of cognitive and motor scores. Children born \u226433\u2009weeks had the worst outcomes, with age\u2010adjusted cognitive and motor composite scores 11 (95% CI, 5\u201317) and 15 (95% CI, 8\u201322) points lower, respectively, than those born at term. Other significant predictors included lower caregiver education, Black race, longer hospitalization, and genetic diagnosis. These models explained 17% to 26% of the variance in Bayley scores. The highest explained variance was in the motor domain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Prematurity is a significant risk factor for adverse cognitive and motor outcomes in children with CHD, especially in those born \u226433\u2009weeks. Enhanced neurodevelopmental surveillance and targeted early intervention strategies are warranted for this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047668","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:54:07Z","timestamp":1787226847000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Prematurity Predicts Neurodevelopmental Outcomes in Congenital Heart Disease"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4852-6752","authenticated-orcid":false,"given":"Jenna A.","family":"Katz","sequence":"first","affiliation":[{"name":"Boston Children's Hospital","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-3226","authenticated-orcid":false,"given":"Kimberlee","family":"Gauvreau","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston, USA"]},{"name":"Boston Children's Hospital","place":["Boston, USA"]},{"name":"Harvard School of Public Health","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8576-7179","authenticated-orcid":false,"given":"Samantha C.","family":"Butler","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-0591","authenticated-orcid":false,"given":"Anjali","family":"Sadhwani","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5103-5834","authenticated-orcid":false,"given":"Philip T.","family":"Levy","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3450-4496","authenticated-orcid":false,"given":"Aditya","family":"Kaza","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-1382","authenticated-orcid":false,"given":"Meena","family":"Nathan","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7794-9017","authenticated-orcid":false,"given":"Jane W.","family":"Newburger","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston, USA"]},{"name":"Boston Children's Hospital","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.05.059"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0397"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.08.039"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02245.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.08.021"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2015.11.011"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-05419-w"},{"key":"e_1_3_1_10_2","volume-title":"Bayley Scales of Infant and Toddler Development\u00ae 3rd Edition (Bayley\u2010III\u00ae)","author":"Bayley N","year":"2006","unstructured":"Bayley N. 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