{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:39:50Z","timestamp":1791833990398,"version":"4.3.4"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">High\u2010potency P2Y12 receptor inhibitors (ticagrelor and prasugrel) reduce ischemic outcomes compared with clopidogrel among patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). This study aims to examine contemporary trends and identify predictors of their use among patients with AMI undergoing PCI in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This observational study used electronic health records from &gt;95 US\u2010based health care organizations. Adults with AMI who underwent PCI between 2016 and 2023 were included. The primary outcome was the prescription of high\u2010potency P2Y12 receptor inhibitors versus clopidogrel. Multivariable logistic regression was used to identify independent predictors of P2Y12 inhibitor selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 182\u2009986 patients with\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">AMI<\/jats:styled-content>\n                      who underwent\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">PCI<\/jats:styled-content>\n                      , clopidogrel was the most prescribed\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">P2Y12<\/jats:styled-content>\n                      receptor inhibitor (101\u2009136 patients, 55.2%), followed by ticagrelor (68\u2009350, 37.4%) and prasugrel (13\u2009500, 7.4%). Clopidogrel use declined from 66.2% in 2016 to 51.4% in 2023 (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      =0.002), whereas ticagrelor use increased from 27.8% to 39.4% (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      =0.022), and prasugrel use increased from 6.0% to 9.2% (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      =0.008), predominantly after 2019. High\u2010potency\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">P2Y12<\/jats:styled-content>\n                      receptor inhibitors were more frequently used in younger patients (&lt;60\u2009years), those with prior\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">PCI<\/jats:styled-content>\n                      , prior\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">MI<\/jats:styled-content>\n                      , chronic kidney disease, and morbid obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among patients with\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">AMI<\/jats:styled-content>\n                      undergoing PCI, the use of high\u2010potency agents continues to rise. Prasugrel use increased notably after 2019, following the ISAR\u2010REACT 5 (Prospective, Randomized Trial of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome) trial and the European guideline updates. These findings reflect an evolving prescribing landscape of P2Y12 receptor inhibitors in contemporary practice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047683","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:07:12Z","timestamp":1773832032000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Contemporary Trends in High\u2010Potency P2Y12 Receptor Inhibitor Use Among Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-1692","authenticated-orcid":false,"given":"Ayman R.","family":"Fath","sequence":"first","affiliation":[{"name":"University of Texas Health Science Center","place":["San Antonio, USA"]},{"name":"Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis Heart 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