{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:08:55Z","timestamp":1789013335378,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">In the general population, elevated hs\u2010cTnI (high\u2010sensitivity cardiac troponin I) levels are linked to adverse cardiovascular outcomes. Whether changes in hs\u2010cTnI within the normal range are associated with variations in cardiovascular risk scores remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This observational substudy of the CV\u2010PREVITAL (Strategies for Primary Cardiovascular Prevention in the Italian Population) project evaluated 810 subjects (522 women) in primary prevention. Hs\u2010cTnI was measured at baseline and after 12 months in 473 participants. Cardiovascular risk was assessed using validated scores along with diet adherence and sleep quality. Clinical and laboratory parameters were recorded. Participants received structured lifestyle counseling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      At baseline, hs\u2010cTnI was undetectable in 59% of participants. Detectable hs\u2010cTnI was associated with older age (58 versus 55\u2009years), higher body mass index (26 versus 24 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), greater waist circumference (91 versus 85 cm), higher blood pressure (129 versus 123\u2009mm Hg), lower high\u2010density lipoprotein cholesterol (56 versus 59 mg\/dL), higher glycated hemoglobin (40 versus 38\u2009mmol\/mol), all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01. Progetto Cuore, Framingham Risk Score, Atherosclerotic Cardiovascular Disease, and Finnish Diabetes Risk scores were higher (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.0001) in participants with detectable hs\u2010cTnI, whereas the Moli\u2010sani risk score did not differ. At 12 months, participants with undetectable hs\u2010cTnI increased to 79% (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.0001). Although all scores but 1 improved at follow\u2010up, changes in hs\u2010cTnI were not consistently associated with changes in risk scores or therapy modifications in exploratory analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this primary\u2010prevention cohort, the presence of detectable hs\u2010cTnI was associated with a less favorable risk profile. However, its usefulness in the longitudinal monitoring of cardiovascular risk changes requires validation against cardiovascular outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047689","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T10:19:54Z","timestamp":1784974794000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Changes in High\u2010Sensitivity Cardiac Troponin I Levels Associate With Variations in Cardiovascular Risk Scores in the General Population"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1612-5329","authenticated-orcid":false,"given":"Tiziana","family":"Bachetti","sequence":"first","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS, Scientific Institute of Pavia","place":["Pavia, 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