{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:28Z","timestamp":1789715008459,"version":"4.0.1"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Antimicrobial use (AMU) in acute myocardial infarction\u2013related cardiogenic shock is common, but its prevalence, drivers, and outcomes are not well described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We analyzed 1095 patients with acute myocardial infarction\u2013related cardiogenic shock from the multicenter Northwell\u2010Shock Registry (2016\u20132022). Patients undergoing coronary artery bypass surgery were excluded. AMU was defined as \u226524\u2009hours of continuous therapy. Clinical features and outcomes were compared between AMU+ and AMU\u2212 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Antimicrobials were used in 55% of patients, and 70% of them were initiated within 48 hours of admission. Positivity was low in AMU+ cultures (12.6% blood, 20.4% urine), and resistant organisms were found in only 9.5% of positive blood cultures. In 70% of patients, AMU was prolonged despite negative cultures. Broad\u2010spectrum agents were used in 84.9%. Anti\u2013methicillin\u2010resistant\n                      <jats:italic toggle=\"no\">Staphylococcus aureus<\/jats:italic>\n                      and antipseudomonal agents were used in &gt;70% of patients with AMU. While length of stay was longer in AMU+ patients (11 versus 4\u2009days,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01), the overall mortality rate was similar (35.2% versus 37.2%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.485).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">More than half of patients with acute myocardial infarction\u2013related cardiogenic shock received antimicrobials. Most patients received broad\u2010spectrum coverage despite low microbial culture yield and the rare isolation of resistant organisms. These findings highlight the need for targeted stewardship strategies to optimize AMU in acute myocardial infarction\u2013related cardiogenic shock.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047751","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T16:30:03Z","timestamp":1774801803000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial Use in Acute Myocardial Infarction\u2013Related Cardiogenic Shock"],"prefix":"10.1161","volume":"15","author":[{"given":"Abduljabar","family":"Adi","sequence":"first","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, USA"]},{"name":"Lenox Hill Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Jain","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, USA"]},{"name":"Lenox Hill Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satvinder","family":"Guru","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, USA"]},{"name":"Lenox Hill Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Calvo","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, USA"]},{"name":"Lenox Hill Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechen","family":"Samdrup","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, USA"]},{"name":"Lenox Hill Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapana","family":"Yonghang","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, USA"]},{"name":"Lenox Hill 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USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcy","family":"Miller","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, USA"]},{"name":"Lenox Hill Hospital","place":["New York, USA"]},{"name":"The Feinstein Institutes for Medical Research","place":["Manhasset, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Roubin","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, USA"]},{"name":"Lenox Hill Hospital","place":["New York, USA"]},{"name":"The Feinstein Institutes for Medical Research","place":["Manhasset, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Diakos","sequence":"additional","affiliation":[{"name":"The Texas Heart Institute","place":["Houston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6408-1821","authenticated-orcid":false,"given":"Matthew","family":"Pierce","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, USA"]},{"name":"North Shore University Hospital","place":["Manhasset, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Griffin","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, USA"]},{"name":"North Shore University Hospital","place":["Manhasset, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2871-3865","authenticated-orcid":false,"given":"Miguel","family":"Alvarez Villela","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, USA"]},{"name":"Lenox Hill Hospital","place":["New York, 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