{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:26Z","timestamp":1789715006213,"version":"4.0.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Despite the role of cardiac catheterization for hemodynamic assessment and endomyocardial biopsy in children with cardiomyopathy, data on procedure\u2010related major adverse events (MAE) in this population are lacking. We aim to describe the rate of MAE in children with cardiomyopathy undergoing cardiac catheterization. Our secondary objective is to compare the rate of MAE among patient subsets within this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We included patients with cardiomyopathy from the National Cardiovascular Data Registry IMPACT (Improving Pediatric and Adult Congenital Treatment) who were 18\u2009years old or younger and underwent cardiac catheterization between April 2016 and December 2024. Data collected included demographic, preprocedural, procedural, and outcome\u2010related variables. We performed univariate and multivariate analyses to identify variables independently associated with MAE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">A total of 4932 procedures were evaluated, with a median age of 10\u2009years. Dilated cardiomyopathy was the most prevalent cardiomyopathy in 53.4%. The rate of MAE was 3.17%. The most common MAE was arrhythmia, representing 42.3% of all MAE. The multivariate analysis also revealed that age &lt;1 year, hypertrophic cardiomyopathy compared with dilated cardiomyopathy, preprocedural inotropic support, left femoral venous access, and systemic heparinization were associated with an increased rate of MAE. In contrast, procedures performed electively were associated with a lower risk of MAE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiac catheterization in pediatric patients with cardiomyopathy was associated with low incidence of MAE as compared with the general pediatric population. Factors associated with an increased rate of MAE include age &lt;1\u2009year, hypertrophic cardiomyopathy, inotropic support, left femoral venous access, and systemic heparinization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047780","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:23:06Z","timestamp":1774430586000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Major Adverse Events of Cardiac Catheterization in Pediatric Cardiomyopathy: Insights From the IMPACT Registry"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0163-8658","authenticated-orcid":false,"given":"Khalifah A.","family":"Aldawsari","sequence":"first","affiliation":[{"name":"University of Colorado","place":["Aurora, USA"]},{"name":"Nicklaus Children\u2019s Hospital","place":["Miami, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin F.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Hospital","place":["Kansas City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro Martinez","family":"Herrada","sequence":"additional","affiliation":[{"name":"Nicklaus Children\u2019s Hospital","place":["Miami, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa021715"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003450","article-title":"Natural history of dilated cardiomyopathy in children","volume":"5","author":"Puggia I","year":"2024","unstructured":"Puggia I, Merlo M, Barbati G, Rowland TJ, Stolfo D, Gigli M, Ramani F, Di Lenarda A, Mestroni L, Sinagra G. Natural history of dilated cardiomyopathy in children. J Am Heart Assoc. 2024;5:e003450.","journal-title":"J Am Heart Assoc"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001151"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.104638"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000682"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31821b1f10"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.02.034"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx200"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.117.008142"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0391398820953860"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1416-5"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00452-0"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028895"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24802"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00128"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14482"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.04.023"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.10.004"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22817"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.01.020"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.047780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:34:40Z","timestamp":1789713280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.047780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,4,7]]}},"alternative-id":["10.1161\/JAHA.125.047780"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.047780","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"2025-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e047780"}}