{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:31:04Z","timestamp":1793802664630,"version":"4.6.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The arterial pulsatility index (API) is a promising hemodynamic surrogate of left ventricular function, but its prognostic value in acute myocardial infarction\u2010related cardiogenic shock (AMI\u2010CS) remains unclear. This study evaluated associations between API, a modified API (mAPI), clinical characteristics, and in\u2010hospital outcomes in AMI\u2010CS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with AMI\u2010CS in the multicenter CSWG (Cardiogenic Shock Working Group) registry with available API or mAPI were analyzed. API was calculated as systemic arterial pulse pressure\/pulmonary capillary wedge pressure; mAPI used pulmonary artery diastolic pressure instead of wedge pressure. Logistic\/linear regression, spline modeling, and receiver operating characteristic curve analysis were used to assess associations with clinical characteristics and in\u2010hospital outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 487 patients with AMI\u2010CS, median API and mAPI were 2.1 (interquartile range [IQR], 1.3\u20133.2; n=139) and 1.7 (IQR, 1.0\u20132.8; n=487), respectively. API strongly correlated with mAPI (Pearson\n                      <jats:italic toggle=\"no\">r<\/jats:italic>\n                      =0.75,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Native heart survival was lower in patients with low API (41.4% versus 59.4%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.051) or mAPI (41.2% versus 59.1%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Lower API or mAPI correlated with reduced left ventricular ejection fraction and was associated with higher in\u2010hospital mortality (47.1% versus 24.6%; odds ratio [OR], 2.728 [95% CI, 1.341\u20135.705];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.006; and 44.1% versus 32.2%; OR, 1.657 [95% CI, 1.147\u20132.402];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.007). Every 0.5\u2010unit decrease in API or mAPI was associated with a 2.4% (\u03b2=0.024 [95% CI, 0.002\u20130.045];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.030) and 1.4% (\u03b2=0.014 [95% CI, 0.002\u20130.026];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.022) increase in in\u2010hospital mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In AMI\u2010CS, lower API and mAPI were associated with increased mortality. API and mAPI may facilitate early risk assessment and guide tailored treatment decisions in AMI\u2010CS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047854","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:39:37Z","timestamp":1787225977000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Arterial Pulsatility Index in Acute Myocardial Infarction\u2010Related Cardiogenic Shock: Clinical Characteristics and Association With Outcomes"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-2211","authenticated-orcid":false,"given":"Jonas","family":"Sundermeyer","sequence":"first","affiliation":[{"name":"University Heart and Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf","place":["Hamburg, Germany"]},{"name":"The Cardiovascular Center, Tufts Medical Center","place":["Boston, USA"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck","place":["Hamburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Li","sequence":"additional","affiliation":[{"name":"Medical City Healthcare","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8287-2571","authenticated-orcid":false,"given":"Van\u2010Khue","family":"Ton","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9065-7687","authenticated-orcid":false,"given":"Rachna","family":"Kataria","sequence":"additional","affiliation":[{"name":"Brown University Health Cardiovascular Institute","place":["Providence, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-476X","authenticated-orcid":false,"given":"Elric","family":"Zweck","sequence":"additional","affiliation":[{"name":"Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich\u2010Heine\u2010University","place":["D\u00fcsseldorf, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7510-075X","authenticated-orcid":false,"given":"A. Reshad","family":"Garan","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-5268","authenticated-orcid":false,"given":"Manreet K.","family":"Kanwar","sequence":"additional","affiliation":[{"name":"University of Chicago","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-7486","authenticated-orcid":false,"given":"Jaime","family":"Hernandez\u2010Montfort","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure Program Clinic","place":["Temple, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6249-2598","authenticated-orcid":false,"given":"Shashank S.","family":"Sinha","sequence":"additional","affiliation":[{"name":"Inova Fairfax Campus","place":["Falls Church, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8291-6658","authenticated-orcid":false,"given":"Jacob","family":"Abraham","sequence":"additional","affiliation":[{"name":"Providence St. Joseph Research Network","place":["Portland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3382-0294","authenticated-orcid":false,"given":"Kevin J.","family":"John","sequence":"additional","affiliation":[{"name":"The Cardiovascular Center, Tufts Medical Center","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paavni","family":"Sangal","sequence":"additional","affiliation":[{"name":"The Cardiovascular Center, Tufts Medical Center","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8409-8030","authenticated-orcid":false,"given":"Claudius","family":"Mahr","sequence":"additional","affiliation":[{"name":"Medical City Healthcare","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9200-2385","authenticated-orcid":false,"given":"Peter S.","family":"Natov","sequence":"additional","affiliation":[{"name":"The Cardiovascular Center, Tufts Medical Center","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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