{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:53:53Z","timestamp":1791636833392,"version":"4.3.4"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">To date, &gt;10 million children have been conceived via assisted reproductive technology (ART) globally. However, there are some concerns about potential adverse outcomes associated with ART\u2010conceived pregnancies, including the risk of congenital heart defects (CHDs). This meta\u2010analysis aimed to evaluate the association between ART and the risk of major CHDs as well as their specific subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Major electronic databases were screened for studies comparing the incidence of CHD following ART\u2010conceived pregnancies versus spontaneous conception. The primary end point was study\u2010defined incidence of CHDs. Secondary end points included incidence of tetralogy of Fallot, transposition of the great arteries, aortic coarctation, ventricular septal defect, atrial septal defect, pulmonary valve atresia, tricuspid valve atresia, and hypoplastic left heart. Pairwise meta\u2010analyses were performed using frequentist random\u2010effect models to calculate risk ratios and 95% CIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Thirteen studies, encompassing a total of 45\u2009916\u2009925 subjects (4986 conceived via ART), were included in the quantitative synthesis. ART was significantly associated with a higher risk of major CHD compared with natural pregnancy (risk ratio, 2.35 [95% CI, 1.68\u20133.28]), with significant heterogeneity across the studies. An increased risk of tetralogy of Fallot, ventricular septal defect, and atrial septal defect following ART\u2010conceived pregnancies was found, while no difference was found on other CHDs. Prespecified sensitivity analyses were in line with the primary findings of the meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our meta\u2010analysis shows a potential link between ART and increased risk of major CHDs, particularly on tetralogy of Fallot, ventricular septal defect, and atrial septal defect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047875","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:08:39Z","timestamp":1791634119000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Assisted Reproductive Technology and Risk of Congenital Heart Defects in the Offspring: A Systematic Review and 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Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0157-7242","authenticated-orcid":false,"given":"Giovanni","family":"Occhipinti","sequence":"additional","affiliation":[{"name":"University of Catania","place":["Catania, Italy"]},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-1043","authenticated-orcid":false,"given":"Andrea","family":"Caff\u00e8","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5441-9276","authenticated-orcid":false,"given":"Francesco M.","family":"Animati","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, 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