{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:55:25Z","timestamp":1791474925721,"version":"4.3.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Obesity and autoimmune diseases (AIDs) are each associated with elevated risk of cardiovascular and thromboembolic events. Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) have demonstrated cardiovascular and metabolic benefits in patients with type 2 diabetes and obesity, but their effects in patients with obesity and comorbid AID remain uncertain. This study evaluated the association between GLP\u20101RA use and major adverse cardiovascular and thromboembolic event risk among adults with obesity and AID.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This retrospective cohort study emulated a target trial using 2014 to 2024 electronic health record data from the OneFlorida+ network. Adults (aged \u226518\u2009years) with AID and obesity eligible for antiobesity medication therapy were included. Exposure was defined as GLP\u20101RA use versus nonuse. Participants were matched using 1:1 time\u2010dependent propensity scores. The primary outcomes were myocardial infarction, stroke or transient ischemic attack, pulmonary embolism, venous thromboembolism, and coronary revascularization. Secondary outcomes included hospitalization, emergency department visits, and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We matched 13\u2009204 GLP\u20101RA users and 13\u2009204 nonusers (mean \u00b1 SD age, 54.7\u2009\u00b1\u200914.5\u2009years; 73.4% women; mean body mass index, 37\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). GLP\u20101RA use was associated with lower hazard of stroke\/transient ischemic attack (hazard ratio [HR], 0.87 [95% CI, 0.76\u20130.99];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.039), pulmonary embolism (HR, 0.69 [95% CI, 0.56\u20130.86];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.001), venous thromboembolism (HR, 0.83 [95% CI, 0.72\u20130.95];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.007), emergency department visits (HR, 0.79 [95% CI, 0.75\u20130.83];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), and mortality (HR, 0.56 [95% CI, 0.47\u20130.66];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among adults with obesity and AID, GLP\u20101RA use was associated with reduced thromboembolic events, lower emergency department use, and decreased mortality, suggesting potential cardiovascular and survival benefits in this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047893","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T18:00:16Z","timestamp":1780768816000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Glucagon\u2010Like Peptide\u20101 Receptor Agonists and Cardiovascular Events in Adults With Obesity and Autoimmune Disease: A Target Trial Emulation"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7950-3759","authenticated-orcid":false,"given":"Hao","family":"Dai","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine","place":["Indianapolis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao An","family":"Lee","sequence":"additional","affiliation":[{"name":"Regenstrief Institute","place":["Indianapolis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1515-5800","authenticated-orcid":false,"given":"Austin","family":"Natalie","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5223-9522","authenticated-orcid":false,"given":"Whitney","family":"Jackson","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5982-7246","authenticated-orcid":false,"given":"Angela","family":"Pham","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Levine","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rotana M.","family":"Radwan","sequence":"additional","affiliation":[{"name":"Regenstrief Institute","place":["Indianapolis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-2592","authenticated-orcid":false,"given":"Jingchuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Regenstrief Institute","place":["Indianapolis"]},{"name":"Purdue University College of Pharmacy","place":["Indianapolis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2238-5429","authenticated-orcid":false,"given":"Jiang","family":"Bian","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine","place":["Indianapolis"]},{"name":"Regenstrief Institute","place":["Indianapolis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9589-7727","authenticated-orcid":false,"given":"Amy J.","family":"Sheer","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine","place":["Gainesville"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","volume-title":"Adult Obesity Facts","author":"Centers for Disease Control and Prevention","year":"2024","unstructured":"Centers for Disease Control and Prevention . 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