{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:02:37Z","timestamp":1785250957383,"version":"3.55.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Combining PCSK9 (proprotein convertase subtilisin\/kexin type 9) inhibitors with statins significantly lowers low\u2010density lipoprotein cholesterol and reduces cardiovascular events in patients with coronary heart disease versus statins alone. However, it remains unclear which monotherapy offers greater cardiovascular benefit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This prospective non\u2010randomized real\u2010world observational cohort study enrolled coronary heart disease inpatients from July 2020 to March 2024. Patients received either alirocumab (75\u2009mg\/2\u2009weeks) or statins (atorvastatin 20\u2009mg\/day or rosuvastatin 10\u2009mg\/day). The primary outcome was a composite of cardiovascular death, myocardial infarction, stroke, heart failure hospitalization, or coronary revascularization. Cox proportional hazards models and restricted mean survival time analyses were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 1165 analyzed patients, 215 received PCSK9 inhibitors and 950 received statins. After 1\u2009month, low\u2010density lipoprotein cholesterol reduction was greater in the PCSK9 inhibitor group (from 2.57 to 0.75\u2009mmol\/L) than in the statin group (from 2.29 to 1.40\u2009mmol\/L;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). However, this difference was not significant at 12\u2009months (1.44 versus 1.52\u2009mmol\/L;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.058). Multivariate Cox regression analysis revealed an adjusted hazard ratio of 0.74 (95% confidence interval, 0.49\u20131.12;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.152) for the primary outcome with statins versus PCSK9 inhibitors. The restricted mean survival time was 26.11\u2009months for the PCSK9 inhibitor group and 26.48\u2009months for the statin group. The results were consistent across key subgroups. No serious adverse events occurred during the follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">PCSK9 inhibitor monotherapy showed no statistically significant difference from statin monotherapy in long\u2010term lipid\u2010lowering efficacy or cardiovascular risk reduction, suggesting it may be an effective alternative for secondary prevention in coronary heart disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047923","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:40:22Z","timestamp":1776850822000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy of Statins Versus PCSK9 Inhibitors in Coronary Heart Disease Treatment"],"prefix":"10.1161","volume":"15","author":[{"given":"Linchan","family":"Yu","sequence":"first","affiliation":[{"name":"Fangta Traditional Chinese Medicine Hospital of Songjiang District","place":["Shanghai, China"]},{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyang","family":"Xiang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Ren","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Soochow University","place":["Suzhou, 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