{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:08:43Z","timestamp":1789013323970,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transthyretin amyloid cardiomyopathy (ATTR\u2010CM) is a progressive, fatal disease associated with a substantial health care system burden. The aim of this study was to compare health care resource utilization and associated costs among individuals with ATTR\u2010CM, with non\u2010amyloid heart failure (HF), and without HF in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Optum's de\u2010identified Clinformatics Data Mart Database (January 2016 to September 2023) was used to identify patients with ATTR\u2010CM based on HF and\/or cardiomyopathy claims within 2\u2009years of the first ATTR diagnosis. Patients with ATTR\u2010CM were matched to patients with non\u2010amyloid HF (HF\/cardiomyopathy without ATTR) and non\u2010HF controls using 1:1 propensity score matching. All\u2010cause and cardiovascular\u2010related hospitalizations and costs were compared during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Each matched cohort included 4571 patients (mean age, 75.3\u201375.5\u2009years; 56.0%\u201356.6% male; mean follow\u2010up: 2.9\u20133.2\u2009years). The ATTR\u2010CM, non\u2010amyloid HF, and non\u2010HF cohorts had 3.3, 2.7, and 1.5 all\u2010cause hospitalizations per patient during follow\u2010up, respectively. Compared with non\u2010amyloid HF, patients with ATTR\u2010CM had a longer mean length of stay per hospitalization (all\u2010cause and cardiovascular\u2010related: 8.0 versus 7.5\u2009days;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), a greater mean number of days hospitalized annually per patient (all\u2010cause: 10.6 versus 8.4; cardiovascular\u2010related: 10.5 versus 8.3 [both\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001]), and higher mean annual inpatient hospitalization costs per patient (all\u2010cause: $42\u2009868 versus $36\u2009061; cardiovascular\u2010related: $42\u2009841 versus $36\u2009027 [both\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001]). In ATTR\u2010CM subgroups, mean cardiovascular\u2010related length of stay and days hospitalized were higher among patients aged 46 to 64\u2009years and 65 to 80\u2009years (versus &gt;80\u2009years), Black patients (versus White patients), and patients in the Northeast or South US regions (versus the West region).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">ATTR\u2010CM is associated with a higher health care resource utilization\/cost burden than non\u2010amyloid HF and the general population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.047930","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T10:15:42Z","timestamp":1784974542000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Health Care Resource Utilization in Transthyretin Amyloid Cardiomyopathy Compared With Non\u2010amyloid Heart Failure and the General Population"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-3196","authenticated-orcid":false,"given":"Justin L.","family":"Grodin","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-6526","authenticated-orcid":false,"given":"Ahmad","family":"Masri","sequence":"additional","affiliation":[{"name":"Oregon Health and Sciences University","place":["Portland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3590-3274","authenticated-orcid":false,"given":"Richard","family":"Wright","sequence":"additional","affiliation":[{"name":"Pacific Heart Institute","place":["Santa Monica, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8892-4488","authenticated-orcid":false,"given":"Jean\u2010Fran\u00e7ois","family":"Tamby","sequence":"additional","affiliation":[{"name":"BridgeBio Pharma, Inc.","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-215X","authenticated-orcid":false,"given":"Heather","family":"Falvey","sequence":"additional","affiliation":[{"name":"BridgeBio Pharma, Inc.","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4960-6342","authenticated-orcid":false,"given":"Liana","family":"Hennum","sequence":"additional","affiliation":[{"name":"BridgeBio Pharma, Inc.","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9019-3747","authenticated-orcid":false,"given":"Margarita","family":"Udall","sequence":"additional","affiliation":[{"name":"BridgeBio Pharma, Inc.","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitanya","family":"Badwe","sequence":"additional","affiliation":[{"name":"Definitive Healthcare","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Allison","sequence":"additional","affiliation":[{"name":"Definitive Healthcare","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Definitive Healthcare","place":["Bengaluru, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shradha","family":"Sanghi","sequence":"additional","affiliation":[{"name":"Definitive Healthcare","place":["Bengaluru, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-0583","authenticated-orcid":false,"given":"Sandesh","family":"Dev","sequence":"additional","affiliation":[{"name":"Arizona State University","place":["Scottsdale, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5481-2122","authenticated-orcid":false,"given":"Jose","family":"Nativi\u2010Nicolau","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Jacksonville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","volume-title":"StatPearls [Internet]","author":"Jain A","year":"2023","unstructured":"Jain A, Zahra F. Transthyretin amyloid cardiomyopathy (ATTR\u2010CM). StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. 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Help clarify market dynamics and uncover insights with claims data\u00a0[Internet]. 2024. Accessed November 1 2024. https:\/\/www.optum.com\/content\/dam\/o4\u2010dam\/resources\/pdfs\/sell\u2010sheets\/rwd\u2010cdm\u2010sell\u2010sheet.pdf"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0001"},{"key":"e_1_3_2_18_2","volume-title":"Healthcare Cost and Utilization Project (HCUP) Statistical Briefs","author":"Owens PL","year":"2022","unstructured":"Owens PL, Liang L, Barrett ML, Fingar KR. Comorbidities associated with adult inpatient stays, 2019 [Internet]. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville, MD: Agency for Healthcare Research and Quality (US); 2022. Accessed June 10, 2026. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK588380\/"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2147\/rmhp.s97248"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.12.063"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S207127"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-020-00194-4"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11082148"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.047930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:42:12Z","timestamp":1789011732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.047930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":22,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,8,4]]}},"alternative-id":["10.1161\/JAHA.125.047930"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.047930","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"assertion":[{"value":"2025-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e047930"}}