{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:04:58Z","timestamp":1789535098712,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Heart failure is associated with renal function decline and increased morbidity and death. We evaluated the association of systolic blood pressure control over time, measured by time in target range (TTR), with renal function decline and death in patients with heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We analyzed a multicenter prospective cohort of patients hospitalized for heart failure across 52 hospitals in China between 2016 and 2018. Systolic blood pressure was measured at 1, 6, and 12 months after discharge. The 12\u2010month systolic blood pressure TTR was calculated by linear interpolation for a target range of 110 to 130\u2009mm\u2009Hg. Outcomes were 1\u2010year renal function decline (\u226520% reduction in estimated glomerular filtration rate from 1 to 12 months plus estimated glomerular filtration rate &lt;60 mL\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      at 12 months) and 5\u2010year all\u2010cause death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The analysis included 1529 patients for renal function decline and 2195 patients for death. Median follow\u2010up was 1.0 and 4.2\u2009years, respectively. Renal function decline and death decreased significantly from the lowest to highest TTR tertile (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      &lt;0.001 and 0.009, respectively), supported by restricted cubic spline analyses. After multivariable adjustment, each 1\u2010SD increase in TTR (35%\u201336%) was associated with lower risks of renal function decline (odds ratio, 0.74 [95% CI, 0.60\u20130.93];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.008) and all\u2010cause death (hazard ratio, 0.90 [95% CI, 0.83\u20130.98];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.01). Results were consistent across subgroups, using 6\u2010month TTR, and for cardiovascular death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Better long\u2010term systolic blood pressure control, assessed by TTR, was independently associated with lower risks of renal function decline and long\u2010term death in patients with heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration Information<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      Identifier: NCT02878811\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048006","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:51:28Z","timestamp":1788965488000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Improved Long\u2010Term Systolic Blood Pressure Control Measured by Time in Target Range Is Associated With Lower Risks of Renal Function Decline and Long\u2010Term Death Among Patients With Heart Failure"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5386-4975","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases","place":["Beijing, China"]},{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkuo","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-8779","authenticated-orcid":false,"given":"Xinghe","family":"Huang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1192-2726","authenticated-orcid":false,"given":"Jiamin","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6514-2729","authenticated-orcid":false,"given":"Mian","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]},{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1045-8309","authenticated-orcid":false,"given":"Yu","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]},{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6153-5568","authenticated-orcid":false,"given":"Haibo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases","place":["Beijing, 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