{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:04:36Z","timestamp":1789535076774,"version":"build-2803163510"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cluster of differentiation 147 (CD147) is a multifunctional transmembrane glycoprotein, but its effect on poststroke cognitive impairment (PSCI) is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">The current study included 612 patients with ischemic stroke with plasma CD147 levels from a preplanned ancillary study of CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). Mini\u2010Mental State Examination and Montreal Cognitive Assessment were used to evaluate cognitive function at the 3\u2010month follow\u2010up visit. PSCI was defined as a score of &lt;27 for Mini\u2010Mental State Examination or &lt;25 for Montreal Cognitive Assessment. Logistic regression models and restricted cubic spline analyses were used to assess the associations between CD147 and PSCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      As defined by Mini\u2010Mental State Examination, 317 participants developed PSCI. After multivariate adjustment, elevated plasma CD147 levels were significantly associated with higher odds of PSCI (odds ratio, 1.75 [95% CI, 1.21\u20132.51]). Multiple\u2010adjusted spline regression model showed a linear association between plasma CD147 level and PSCI (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      for linearity=0.038). Furthermore, adding plasma CD147 to conventional risk factors improved the discriminatory power (C statistics, 0.695 versus 0.711;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.047). Similar findings were observed when PSCI was defined by the Montreal Cognitive Assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Elevated plasma CD147 levels at admission were associated with higher odds of cognitive impairment at 3\u2009months after stroke among patients with acute ischemic stroke, suggesting its potential role in the pathophysiological processes of PSCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT01840072\">https:\/\/clinicaltrials.gov\/study\/NCT01840072<\/jats:ext-link>\n                      ; Unique Identifier: NCT01840072.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048033","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:53:45Z","timestamp":1788965625000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma Cluster of Differentiation 147 and Cognitive Impairment After Acute Ischemic Stroke"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8887-130X","authenticated-orcid":false,"given":"Wenyu","family":"Zhao","sequence":"first","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, 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