{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:38:56Z","timestamp":1792647536442,"version":"4.5.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The AoU (All of Us) Research Program aims to accelerate precision\u2010medicine research. To provide context for the generalizability of findings we benchmarked cardiovascular risk factors and established cardiovascular disease prevalence in AoU against nationally representative estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We included AoU participants enrolled between May 2017 and June 2022 and the NHANES (National Health and Nutrition Examination Survey) 2017 to March 2020 cycle. The AoU Survey cohort included participants who completed the Personal and Family Health History survey (N=185\u2009232). AoU EHR included participants with linked electronic health record (EHR) (N=287\u2009012). We identified cardiovascular risk factors and cardiovascular disease through survey questions in AoU Survey and NHANES, and Systematized Nomenclature of Medicine codes for AoU EHR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">AoU Survey and AoU EHR were older than NHANES (56.1\u00b117\u2009years and 57.6\u00b117\u2009years versus 47.5\u00b118\u2009years) with more female participants (64% and 60% versus 51.8%). Black participants were underrepresented in AoU Survey (9.1%) and overrepresented in AoU EHR (19.9%); 11.5% in NHANES. Prevalence of cardiovascular comorbidities in AoU Survey and NHANES were similar but lower in AoU Survey when age adjusted (eg, hypertension 31.7% in NHANES versus 19.7% in AoU Survey, diabetes 11.3% versus 8%). Black participants had higher unadjusted rates of hypertension, diabetes, coronary artery disease and congestive heart failure than NHANES. AoU EHR with its code\u2010based identification had higher unadjusted prevalence of most cardiovascular comorbidities; differences attenuated with age\u2010adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">AoU includes more historically underrepresented groups, but representation varies by whether cohorts are defined by survey versus EHR availability. Further, disease prevalence can change based on how conditions are ascertained.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048046","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:01:00Z","timestamp":1791633660000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Cardiovascular Risk Factors and Established Cardiovascular Disease Among All of Us Participants: Benchmarking Against National Estimates"],"prefix":"10.1161","volume":"15","author":[{"given":"Mengjing","family":"Yang","sequence":"first","affiliation":[{"name":"Yale School of Public Health","place":["New Haven, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Yale School of Public Health","place":["New Haven, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1466-075X","authenticated-orcid":false,"given":"Tinsae","family":"Admassu","sequence":"additional","affiliation":[{"name":"Yale School of Public Health","place":["New Haven, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-127X","authenticated-orcid":false,"given":"Harlan M.","family":"Krumholz","sequence":"additional","affiliation":[{"name":"Yale School of Public Health","place":["New Haven, USA"]},{"name":"Yale School of Medicine","place":["New Haven, USA"]},{"name":"Yale\u2010New Haven Hospital","place":["New Haven, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8624-4652","authenticated-orcid":false,"given":"Chenxi","family":"Huang","sequence":"additional","affiliation":[{"name":"Yale School of Medicine","place":["New Haven, USA"]},{"name":"Yale\u2010New Haven Hospital","place":["New Haven, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7932-382X","authenticated-orcid":false,"given":"Karthik","family":"Murugiah","sequence":"additional","affiliation":[{"name":"Yale School of Medicine","place":["New Haven, USA"]},{"name":"Yale\u2010New Haven Hospital","place":["New Haven, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1809937"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234962"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030779"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033322"},{"key":"e_1_3_2_6_2","unstructured":"A Researcher's Guide to the All of Us Research Program. Accessed February 16 2026. https:\/\/support.researchallofus.org\/hc\/en\u2010us\/articles\/36820866028052\u2010A\u2010Researcher\u2010s\u2010Guide\u2010to\u2010the\u2010All\u2010of\u2010Us\u2010Research\u2010Program."},{"key":"e_1_3_2_7_2","volume-title":"US National Health and Nutrition Examination Survey","year":"2024","unstructured":"US National Health and Nutrition Examination Survey. US Centers for Disease Control and Prevention; 2024. Accessed November 30, 2024. https:\/\/www.cdc.gov\/nchs\/nhanes.htm."},{"key":"e_1_3_2_8_2","unstructured":"SNOMED International . SNOMED CT. 2024 https:\/\/www.nlm.nih.gov\/healthit\/snomedct\/snomed_overview.html."},{"key":"e_1_3_2_9_2","first-page":"1","article-title":"Age adjustment using the 2000 projected U.S. population","volume":"20","author":"Klein RJ","year":"2001","unstructured":"Klein RJ, Schoenborn CA. Age adjustment using the 2000 projected U.S. population. Healthy People 2010 Stat Notes. 2001;20:1\u201310.","journal-title":"Healthy People 2010 Stat Notes"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2196\/11865"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.039031"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.15187"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocac046"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(99)00069-0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40471-017-0130-z"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.20.2268"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.00490116"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021724"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwaf118"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocad260"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.05.006"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.04.035"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwac169"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.048046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:54:40Z","timestamp":1792644880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.048046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,20]]},"references-count":22,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10,20]]}},"alternative-id":["10.1161\/JAHA.125.048046"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.048046","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,20]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e048046"}}