{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:11Z","timestamp":1787018111955,"version":"build-2736575974"},"reference-count":101,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Long\u2010term survivors of breast cancer (BC) treated with doxorubicin and trastuzumab\u2010based chemotherapy are at increased risk of developing cardiovascular disease. However, the physiological mechanisms associated with increased cardiovascular disease risk are completely unknown. We hypothesized that long\u2010term survivors of BC, compared with controls, exhibit sympathetic neural hyperactivity, vascular dysfunction, cardiac morphofunctional changes, exercise intolerance, and alterations in the circulating milieu.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Twenty\u2010three survivors of BC (age: 48.9\u00b11.3\u2009years; body mass index: 25.2\u00b10.8 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and 18 (age: 46.4\u00b11.3\u2009years; body mass index: 26.8\u00b10.8 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) well\u2010matched controls were studied. Muscle sympathetic nerve activity (microneurography), brachial artery flow\u2010mediated dilation (ultrasound\u2010Doppler), carotid\u2010femoral pulse wave velocity (tonometry), left ventricular ejection fraction and global longitudinal strain (echocardiography), peak oxygen uptake (cardiopulmonary exercise testing), endothelial cell\u2010derived extracellular vesicles (flow cytometry), and plasma metabolome (mass spectrometry) were assessed. Complementary experiments were conducted on human umbilical vein endothelial cells cultured with plasma samples from subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Survivors of breast cancer were tested \u20538\u2009years after cancer treatment completion. Muscle sympathetic nerve activity was higher and brachial artery flow\u2010mediated dilation and peak oxygen uptake were lower in survivors than controls. Survivors of breast cancer exhibited higher circulating endothelial cell\u2010derived extracellular vesicles, higher reactive oxygen species bioactivity, and lower acetylcholine\u2010evoked nitrics oxide production in plasma\u2010treated human umbilical vein endothelial cells. Twenty\u2010eight plasma metabolites differed in survivors versus controls. Peak oxygen uptake was inversely related to muscle sympathetic nerve activity or positively to brachial artery flow\u2010mediated dilation. No differences in carotid\u2010femoral pulse wave velocity, left ventricular ejection fraction, and left ventricular global longitudinal strain were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our findings demonstrate that long\u2010term survivors of breast cancer exhibit sympathetic overdrive, vascular dysfunction, and exercise intolerance, which may contribute to increased cardiovascular disease risk in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048047","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:33:02Z","timestamp":1773401582000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long\u2010Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab\u2010Based Chemotherapy"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-489X","authenticated-orcid":false,"given":"Jo\u00e3o E.","family":"Izaias","sequence":"first","affiliation":[{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["Rio de Janeiro, Brazil"]},{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9795-3745","authenticated-orcid":false,"given":"Artur O.","family":"Sales","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["Rio de Janeiro, Brazil"]},{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4235-3691","authenticated-orcid":false,"given":"Bruna E.","family":"Ono","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["Rio de Janeiro, Brazil"]},{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6075-2448","authenticated-orcid":false,"given":"Thais S.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["Rio de Janeiro, Brazil"]},{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3682-7981","authenticated-orcid":false,"given":"Gabrielly M. P. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0295-2902","authenticated-orcid":false,"given":"Priscilla S.","family":"Pentagna","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3486-5240","authenticated-orcid":false,"given":"Andre L. P.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0387-4933","authenticated-orcid":false,"given":"Flavia N.","family":"Folchini","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-019X","authenticated-orcid":false,"given":"Fernanda M. C.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-3662","authenticated-orcid":false,"given":"Maria C. C.","family":"Irigoyen","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5737-5223","authenticated-orcid":false,"given":"Amanda G.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Negr\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6080-7429","authenticated-orcid":false,"given":"Laura","family":"Testa","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["S\u00e3o Paulo, Brazil"]},{"name":"Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1990-9834","authenticated-orcid":false,"given":"Nat\u00e1lia G.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Fluminense Federal University","place":["Niteroi, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena N. M.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Fluminense Federal University","place":["Niteroi, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-1880","authenticated-orcid":false,"given":"Gabriel F.","family":"Texeira","sequence":"additional","affiliation":[{"name":"Fluminense Federal University","place":["Niteroi, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-2886","authenticated-orcid":false,"given":"Antonio C. L. D.","family":"N\u00f3brega","sequence":"additional","affiliation":[{"name":"Fluminense Federal University","place":["Niteroi, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia A. S.","family":"Miyaguti","sequence":"additional","affiliation":[{"name":"MS4Life Laboratory of Mass Spectrometry, Health Sciences Postgraduate Program, S\u00e3o Francisco University","place":["Bragan\u00e7a Paulista, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex A. R.","family":"Silva","sequence":"additional","affiliation":[{"name":"MS4Life Laboratory of Mass Spectrometry, Health Sciences Postgraduate Program, S\u00e3o Francisco University","place":["Bragan\u00e7a Paulista, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia M.","family":"Porcari","sequence":"additional","affiliation":[{"name":"MS4Life Laboratory of Mass Spectrometry, Health Sciences Postgraduate Program, S\u00e3o Francisco University","place":["Bragan\u00e7a Paulista, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Viana","family":"Nascimento\u2010Filho","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (UNIFESP)","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3640-9049","authenticated-orcid":false,"given":"Katia","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (UNIFESP)","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Craighead","sequence":"additional","affiliation":[{"name":"School of Kinesiology, University of Minnesota","place":["Minneapolis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3878-3533","authenticated-orcid":false,"given":"Zachary S.","family":"Clayton","sequence":"additional","affiliation":[{"name":"University of Colorado Boulder","place":["Boulder, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn R.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"University of Colorado Boulder","place":["Boulder, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9381-2590","authenticated-orcid":false,"given":"Matthew J.","family":"Rossman","sequence":"additional","affiliation":[{"name":"University of Colorado Boulder","place":["Boulder, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2391-9824","authenticated-orcid":false,"given":"Douglas R.","family":"Seals","sequence":"additional","affiliation":[{"name":"University of Colorado Boulder","place":["Boulder, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-7319","authenticated-orcid":false,"given":"Renata","family":"Moll\u2010Bernardes","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5989-2857","authenticated-orcid":false,"given":"Allan R. K.","family":"Sales","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["Rio de Janeiro, Brazil"]},{"name":"D\u2019Or Institute for Research and Education (IDOR)","place":["S\u00e3o Paulo, Brazil"]},{"name":"Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAONCOL.2018.3691"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000394"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/EURJPC\/ZWAD243"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.5935\/ABC.20150075"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/PH17121563"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS23126375"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00756.2018"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.03.056"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/S00408-013-9544-7"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.00476.2023"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI149117"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2020.06.010"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015598"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACCAO.2024.04.006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2023.11.005"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA052122"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.049"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJCA.2018.02.005"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/S10286-014-0226-1"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.104.25.e161"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018448"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/S10286-024-01015-6"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPLPHYSIOL.00470.2003"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53491-0.00028-6"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.GHEART.2016.08.006"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","unstructured":"Stein JH Korcarz CE Hurst RT Lonn E Kendall CB Mohler ER Najjar SS Rembold CM Post WS. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography carotid intima\u2010media thickness task force endorsed by the Society for Vascular Medicine. 2008;21:93\u2013111. doi: 10.1016\/J.ECHO.2007.11.011","DOI":"10.1016\/J.ECHO.2007.11.011"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.ATHEROSCLEROSIS.2019.02.005"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000091"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00471.2010"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/EURHEARTJ\/EHZ350"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/S10877-012-9375-8"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16175"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/ACEL.13074"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2021.04.013"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCMG.2017.11.017"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","unstructured":"Zoppini G Bergamini C Mantovani A Dauriz M Targher G Rossi A Bonora E. The E\/e' ratio difference between subjects with type 2 diabetes and controls: a meta\u2010analysis of clinical studies. 2018;13. doi: 10.1371\/journal.pone.0209794","DOI":"10.1371\/journal.pone.0209794"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2020.105718"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_3_2_40_2","first-page":"S79","article-title":"A new approach to analysis of the arterial baroreflex","volume":"3","author":"Bertinieri G","year":"1985","unstructured":"Bertinieri G, Di Rienzo M, Cavallazzi A, Ferrari AU, Pedotti A, Mancia G. A new approach to analysis of the arterial baroreflex. J Hypertens Suppl. 1985;3:S79\u2013S81.","journal-title":"J Hypertens Suppl"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/FNINS.2019.00017"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0B013E3181E52E69"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192520"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200030010-00003"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP276559"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1152\/AJPREGU.1999.276.1.R197"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_3_2_48_2","first-page":"437","article-title":"Operationalization of clinical study objectives: a precondition for demonstrating efficacy","volume":"30","author":"Rahlfs VW","year":"1992","unstructured":"Rahlfs VW. Operationalization of clinical study objectives: a precondition for demonstrating efficacy. Int J Clin Pharmacol. 1992;30:437\u2013438.","journal-title":"Int J Clin Pharmacol"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2022.812942"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.21577\/0103-5053.20230016"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/S11764-015-0445-Z"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.05.014"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19850"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/FUNCTION\/ZQAE036"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.AUTNEU.2025.103274"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","unstructured":"Frye JN Sutterfield SL Caldwell JT Behnke BJ Copp SW Banister HR Ade CJ. Vascular and autonomic changes in adult cancer patients receiving anticancer chemotherapy. 2018;125:198\u2013204. doi: 10.1152\/JAPPLPHYSIOL.00005.2018","DOI":"10.1152\/JAPPLPHYSIOL.00005.2018"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1124\/JPET.110.174102"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.AUTNEU.2014.10.001"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.1992.262.6.E763"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/CNCR.21478"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-0236"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/APHA.13315"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1152\/JN.1996.75.3.1264"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP277929"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.00625.2005"},{"key":"e_1_3_2_66_2","first-page":"2933","article-title":"Biomarkers of inflammation, hypercoagulability and endothelial injury predict early asymptomatic doxorubicin\u2010induced cardiotoxicity in breast cancer patients","volume":"10","author":"Todorova VK","year":"2020","unstructured":"Todorova VK, Hsu PC, Wei JY, Lopez\u2010Candales A, Chen JZ, Su LJ, Makhoul I. Biomarkers of inflammation, hypercoagulability and endothelial injury predict early asymptomatic doxorubicin\u2010induced cardiotoxicity in breast cancer patients. Am J Cancer Res. 2020;10:2933\u20132945.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1177\/1076029615613159"},{"key":"e_1_3_2_68_2","first-page":"87","article-title":"A method for detection of doxorubicin\u2010induced cardiotoxicity: flow\u2010mediated vasodilation of the brachial artery","volume":"6","author":"Nagy L","year":"2001","unstructured":"Nagy L, Szab\u00f3 F, Iv\u00e1nyi J, N\u00e9meth L, Kov\u00e1cs GL, Palatka J, Tarj\u00e1n J, T\u00f3th K, Roth E. A method for detection of doxorubicin\u2010induced cardiotoxicity: flow\u2010mediated vasodilation of the brachial artery. Exp Clin Cardiol. 2001;6:87\u201392.","journal-title":"Exp Clin Cardiol"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/CVR\/CVT084"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/CKJ\/SFZ042"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1152\/AJPREGU.00055.2025"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00111.2023"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19958"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0009257"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07681"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACCAO.2024.07.016"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023463"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.07.018"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/134679"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCMG.2018.10.039"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.124.011962"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1113\/EP086994"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1634\/THEONCOLOGIST.2019-0777"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBMT.2017.01.006"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001970"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0628"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002469"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac244"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1152\/AJPREGU.00345.2018"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPLPHYSIOL.00394.2018"},{"key":"e_1_3_2_92_2","first-page":"471","article-title":"Sympathetic vasodilatation in human limbs","volume":"526","author":"Joyner MJ","year":"2000","unstructured":"Joyner MJ, Halliwill JR. Sympathetic vasodilatation in human limbs. J Physiol. 2000;526:471\u2013480.","journal-title":"J Physiol"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.01240.2004"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(98)00173-8"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.01.027"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.120402"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(80)90340-3"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606345200"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(99)99005-5"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000176238.90681.13"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(78)52032-6"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.2144\/000113441"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.048047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:11:04Z","timestamp":1782990664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.048047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":101,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3,17]]}},"alternative-id":["10.1161\/JAHA.125.048047"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.048047","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"2025-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eJAHA\/2025\/048047-T"}}