{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:30:22Z","timestamp":1793802622043,"version":"4.6.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"\n Background<\/jats:title>\n \n Individuals residing in the southeastern United States experience disproportionately worse stroke outcomes. Although blood pressure (\n BP<\/jats:styled-content>\n ) reduction is among the most effective strategies for improving stroke outcomes, fewer than one third of survivors of stroke achieve\n BP<\/jats:styled-content>\n control within 1 year of the index event.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The PACESETTER (Program to Avoid Cerebrovascular Events Through Systematic Electronic Tracking and Tailoring of an Eminent Risk Factor) trial enrolled patients with stroke and uncontrolled BP from 3 safety\u2010net health care systems in South Carolina. Patients were randomized 1:1 to the PACESETTER intervention, which included a Bluetooth\u2010enabled electronic pill tray, a BP monitor, and a smartphone application for automated data transmission of medication adherence and BP data to a central server or to usual care. The primary outcome was systolic BP <130\u2009mm\u2009Hg at 12 months, analyzed according to the intention\u2010to\u2010treat principle.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The trial was stopped early due to low recruitment during the COVID\u201019 and funding constraints. Between September 2019 and February 2023, 120 participants were randomized to PACESETTER (n=60) or the usual care arm (n=60). At 4\u00a0months, systolic BP <130\u2009mm\u2009Hg favored the PACESETTER arm (48.8% versus 29.3%,\n P<\/jats:italic>\n =0.07), but no significant difference was observed at 12 months (50% versus 47.2%,\n P<\/jats:italic>\n =0.82).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Because the trial was terminated prematurely, the effect of the PACESETTER intervention on 12\u2010month BP control after stroke remains uncertain. A trial completed to its full term and sufficiently powered to also evaluate key short\u2010term end points is needed.<\/jats:p>\n <\/jats:sec>\n \n Registration<\/jats:title>\n \n URL:\n https:\/\/www.clinicalstrial.org<\/jats:ext-link>\n ; Unique Identifier: NCT03401489.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.125.048147","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:45:35Z","timestamp":1787226335000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Program to Avoid Cerebrovascular Events Through Systematic Electronic Tracking and Tailoring of an Eminent Risk Factor: A\u00a0Randomized Trial"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0638-4776","authenticated-orcid":false,"given":"Parneet","family":"Grewal","sequence":"first","affiliation":[{"name":"Medical University of South Carolina","place":["Charleston, 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