{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:18:44Z","timestamp":1785442724859,"version":"3.56.0"},"reference-count":79,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiovascular disease is a risk factor for severe COVID\u201019 (ie, hospitalization or death). Whether better cardiovascular health (CVH) is associated with lower risk of severe COVID\u201019 among adults without cardiovascular disease is unknown. We aimed to test if the American Heart Association's Life's Essential 8 (LE8) metric and its components were associated with severe COVID\u201019 in the C4R (Collaborative Cohort of Cohorts for COVID\u201019 Research) consortium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Participants with cardiovascular disease were excluded. Two waves of questionnaires, events surveillance, and a serosurvey identified COVID\u201019 infections. Associations of incident severe COVID\u201019 with continuous LE8, categorical LE8 (low [&lt;50], moderate [50 to &lt;80], and high [\u226580] CVH), and individual LE8 components, were tested in adjusted cause\u2010specific hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 29\u2009740 participants in 9 cohorts (mean age, 66\u00b114\u2009years; 61% women; 35% White race; 22% Black race; 34% Hispanic ethnicity), there were 681 severe COVID\u201019 cases between March 1, 2020, and February 28, 2023. There was a 20% lower hazard of severe COVID\u201019 per each 1\u2010SD higher LE8 (adjusted hazard ratio [aHR], 0.80 [95% CI, 0.73\u20130.88]). Relative to low CVH, high CVH was associated with lower risk of severe COVID\u201019 (aHR, 0.54 [95% CI, 0.37\u20130.78]); this was not seen for moderate CVH (aHR, 0.81 [95% CI, 0.64\u20131.04]). Of LE8 components, better physical activity, body mass index, blood pressure, and sleep were associated with a lower hazard of severe COVID\u201019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Better CVH was associated with lower severe COVID\u201019 risk among cardiovascular disease\u2013free adults. Whether CVH optimization could mitigate adverse risk from COVID\u201019 and other harmful viruses warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048256","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:15:18Z","timestamp":1777281318000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Life's Essential 8 and Risk of Severe COVID\u201019 Among Adults Without Clinical Cardiovascular Disease: The C4R Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9992-9597","authenticated-orcid":false,"given":"Timothy B.","family":"Plante","sequence":"first","affiliation":[{"name":"Larner College of Medicine at the University of Vermont","place":["Burlington, 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