{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:59:23Z","timestamp":1785257963146,"version":"3.55.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">While intensive medical therapy improves culprit plaque characteristics in intracranial atherosclerotic steno\u2010occlusive disease, its broader effects on the intracranial arterial tree, venous pathways, and meningeal lymphatic system remain unclear. We explored longitudinal panvascular changes in patients with intracranial atherosclerotic steno\u2010occlusive disease under intensive therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We included patients with a first\u2010ever intracranial atherosclerotic steno\u2010occlusive disease\u2013related stroke who received intensive medical therapy and underwent multimodal magnetic resonance imaging at baseline and 6\u2010month follow\u2010up. Quantitative assessments included plaque burden and lumen area at the culprit artery, global arterial tree morphology, internal jugular vein area, and meningeal lymphatic vessel volume. Associations between low\u2010density lipoprotein cholesterol reduction and vascular metrics were analyzed using adjusted generalized additive models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 24 enrolled patients, plaque burden at the site of maximal stenosis in the culprit artery decreased significantly (mean difference, \u22125.24% [95% CI, \u22129.25% to \u22121.23%]). Global arterial tree length (mean difference, 278.89\u2009mm [95% CI, 26.60\u2013531.18\u2009mm]) and volume (mean difference, 411.38\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      [95% CI, 36.9\u2013785.87\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ]) increased, while the mean arterial diameter decreased (mean difference, \u22120.05\u2009mm [95% CI, \u22120.08 to \u22120.01\u2009mm]). Meningeal lymphatic vessel volume also expanded (mean difference, 337.42\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      [95% CI, 73.08\u2013601.75\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ]). No significant changes were observed in the cross\u2010sectional area of the internal jugular vein. Greater reduction in low\u2010density lipoprotein cholesterol was associated with more pronounced improvements among these panvascular metrics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">These findings reveal coordinated arterial and lymphatic changes beyond local plaque regression. Future studies are warranted to further explore these systemic changes and their clinical implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048257","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:26:33Z","timestamp":1783740393000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Panvascular Changes Under Intensive Medical Therapy in Intracranial Atherosclerotic Steno\u2010Occlusive Disease"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3152-497X","authenticated-orcid":false,"given":"WeiZhuang","family":"Yuan","sequence":"first","affiliation":[{"name":"Sun Yat\u2010sen University","place":["Guangzhou, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8456-0686","authenticated-orcid":false,"given":"Ming\u2010Li","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-9003","authenticated-orcid":false,"given":"Yue\u2010Lun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongrui","family":"Yan","sequence":"additional","affiliation":[{"name":"Jining No. 1 People's Hospital","place":["Jining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1057-0579","authenticated-orcid":false,"given":"Wei\u2010Hai","family":"Xu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00376-8"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.12000"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.11.008"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032242"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-04983-6"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00776.2018"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.125.051719"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24340"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-022-03002-y"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims-22-210"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27561"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-320893"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241228203"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017694391"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003508"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000837"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58726-1"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103353"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.107996"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-023-00558-4"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6212"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14551"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000141145.78900.44"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/79510"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-025-01386-9"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301407"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-102319-103410"}],"container-title":["Journal 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