{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:17:19Z","timestamp":1788329839564,"version":"build-2803163510"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Infarct evolution on diffusion\u2010weighted imaging (DWI) after complete recanalization and its relationships to computed tomography perfusion core and outcome remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">From a multicenter registry (2014\u20132024), we identified 189 patients with anterior\u2010circulation large\u2010vessel occlusion, modified Thrombolysis in Cerebral Infarction grade 3 recanalization, prethrombectomy computed tomography perfusion, immediate DWI within 24\u2009hours, and delayed DWI at 24 to 168\u2009hours. Robust linear regression identified predictors of DWI volume change; logistic regression assessed 90\u2010day modified Rankin Scale scores of 0 to 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      DWI volume increased in 162 of 189 patients (85.7%), from a median of 4.8\u2009mL (interquartile range, 1.1\u201316.4) immediately after thrombectomy to 11.7\u2009mL (interquartile range, 3.8\u201340.2) on delayed imaging; the median change was 4.4\u2009mL (interquartile range, 0.7\u201314.8). Baseline computed tomography perfusion core was method\u2010sensitively associated with greater change in the full model without immediate DWI (\u03b2=0.154 [heteroscedasticity\u2010consistent 95% CI, \u22120.024 to 0.332];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.09; bootstrap 95% CI, 0.018\u20130.336;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.014) and attenuated after immediate DWI adjustment (\u03b2=0.100;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.22; bootstrap\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.077). Each decile increase in volume change was associated with lower odds of functional independence (adjusted odds ratio, 0.81 [95% CI, 0.68\u20130.97];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.021). Delayed DWI showed the best outcome discrimination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">DWI\u2010defined infarct volume increased after complete recanalization and was associated with functional outcome. The core association was method\u2010sensitive and attenuated after accounting for immediate DWI, supporting a possible mediated rather than independent pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048351","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:54:50Z","timestamp":1787226890000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Serial Computed Tomography Perfusion and Diffusion Imaging After Complete Recanalization in Large\u2010Vessel Occlusion"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-9904","authenticated-orcid":false,"given":"Nakhoon","family":"Kim","sequence":"first","affiliation":[{"name":"Seoul National University Bundang Hospital","place":["Seongnam\u2010si, Republic of 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Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4764-5714","authenticated-orcid":false,"given":"Jun Yup","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital","place":["Seongnam\u2010si, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-6610","authenticated-orcid":false,"given":"Jihoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital","place":["Seongnam\u2010si, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-6348","authenticated-orcid":false,"given":"JoonNyung","family":"Heo","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine","place":["Seoul, Republic of 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Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0051-1997","authenticated-orcid":false,"given":"Hee\u2010Joon","family":"Bae","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital","place":["Seongnam\u2010si, Republic of Korea"]},{"name":"Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1544-7713","authenticated-orcid":false,"given":"Baik Kyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital","place":["Seongnam\u2010si, Republic of Korea"]},{"name":"Gyeonggi Provincial Medical Center Icheon Hospital","place":["Icheon, Republic of 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