{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:20:36Z","timestamp":1787721636785,"version":"build-2784847793"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Risk stratification in type 2 long\u2010QT syndrome remains challenging, as QT duration may not fully reflect all underlying arrhythmic vulnerability. We assessed whether an index derived from the T\u2010wave morphology is associated with cardiac events in a cohort with type 2 long\u2010QT syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We retrospectively and prospectively analyzed 54 genotype\u2010confirmed patients with type 2 long\u2010QT syndrome. T\u2010wave morphology in 8 independent leads was assessed using a warping\u2010based index, the T\u2010wave morphology variation (TMV) index, quantifying T\u2010wave morphologic changes from a general population\u2010based reference T\u2010wave. Association with the first lifetime occurrence of a cardiac event, including either syncope or the combined ventricular arrhythmia end point, was tested using univariate and multivariable Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Using the 25th\u2010percentile threshold (TMV\u2264\u221218.41 ms), more negative TMV values indicating greater morphologic changes and a broader or delayed repolarization phase in the T\u2010wave signal relative to the control, as observed in lead I, were significantly associated with increased risk of cardiac event (hazard ratio [HR], 3.505 [95% CI, 1.673\u20137.341];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). The association remained significant after adjustment for corrected QT (HR, 2.92 [95% CI, 1.111\u20137.676];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.03) and after additional adjustment for sex (HR, 3.375 [95% CI, 1.256\u20139.067];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.016), and the T\u2010wave morphology combination score (HR, 4.061 [95% CI, 1.369\u201312.046];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      T\u2010wave morphology abnormalities, quantified using\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">TMV<\/jats:styled-content>\n                      , are associated with a higher risk of cardiac event\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">s<\/jats:styled-content>\n                      after adjustment for corrected\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">QT<\/jats:styled-content>\n                      prolongation, sex, and morphology combination score.\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">TMV<\/jats:styled-content>\n                      could complement current risk stratification strategies, although confirmatory validation in larger, independent, prospective cohorts is pending.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048388","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:33:51Z","timestamp":1782210831000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Stratification of Patients With Type 2 Long\u2010QT Syndrome Through Analysis of T\u2010Wave Morphology"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4078-5968","authenticated-orcid":false,"given":"Neurys","family":"G\u00f3mez","sequence":"first","affiliation":[{"name":"University of Zaragoza","place":["Zaragoza, Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2013Bioingenier\u00eda, Biomateriales y Nanomedicina Zaragoza 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Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3344-1796","authenticated-orcid":false,"given":"Pia","family":"Dahlberg","sequence":"additional","affiliation":[{"name":"Sahlgrenska University Hospital","place":["Gothenburg, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8404-0541","authenticated-orcid":false,"given":"Anneli","family":"Svensson","sequence":"additional","affiliation":[{"name":"Linkoping University","place":["Link\u00f6ping, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8920-7486","authenticated-orcid":false,"given":"Nina","family":"Larsson","sequence":"additional","affiliation":[{"name":"University and Regional Laboratories, Lund University Hospital, Lund University","place":["Lund, 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